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Review of the Geant4-DNA simulation toolkit for radiobiological applications at the cellular and DNA level
https://repo.qst.go.jp/records/84799
https://repo.qst.go.jp/records/84799f982210e-e645-489d-97bf-1f33ef5c3dad
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-12-15 | |||||
| タイトル | ||||||
| タイトル | Review of the Geant4-DNA simulation toolkit for radiobiological applications at the cellular and DNA level | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Kyriakou, Ioanna
× Kyriakou, Ioanna× Dousatsu, Sakata× Ngoc Tran, Hoang× Perrot, Yann× Wook-Geun, Shin× Lampe, Nathanael× Zein, Sara× Claude Bordage, Marie× Guatelli, Susanna× Villagrasa, Carmen× Emfietzoglou, Dimitris× Sébastien, Incerti× Dousatsu, Sakata |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The Geant4-DNA low energy extension of the Geant4 Monte Carlo (MC) toolkit is a continuously evolving MC simulation code permitting mechanistic studies of cellular radiobiological effects. Geant4-DNA considers the physical, chemical, and biological stages of the action of ionizing ra-diation (in the form of x- and γ-ray photons, electrons and β-rays, hadrons, α-particles and a set of heavier ions) in living cells towards a variety of applications ranging from predicting radio-therapy outcomes to radiation protection both on earth and in space. In this work we provide a brief yet concise overview of the progress achieved so far concerning the different physical, physicochemical, chemical, and biological models implemented into Geant4-DNA, highlighting the latest developments. Specifically, the "dnadamage1" and "molecularDNA" applications which enable, for the first time within an open source platform, quantitative predictions of early DNA damage in terms of single-strand-breaks (SSBs), double-strand-breaks (DSBs), and more complex clustered lesions for different DNA structures ranging from the nucleotide level to the entire genome. These developments are critically presented and discussed along with key benchmarking results. The Geant4-DNA toolkit, through its different set of models and functionalities, offers unique capabilities for elucidating the problem of radiation quality or relative biological effec-tiveness (RBE) of different ionizing radiations which underlines nearly the whole spectrum of radiotherapeutic modalities, from external high-energy hadron beams to internal low-energy gamma and beta emitters used in brachytherapy sources and radiopharmaceuticals, respectively. | |||||
| 書誌情報 |
Cancers 巻 14, 号 1, p. 35, 発行日 2021-12 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2072-6694 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.3390/cancers14010035 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.mdpi.com/2072-6694/14/1/35 | |||||
