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Mitophagy reporter mouse analysis reveals increased mitophagy activity in disuse-induced muscle atrophy
https://repo.qst.go.jp/records/84724
https://repo.qst.go.jp/records/847248e2bae56-9afa-4140-b8f5-79017a6b99ac
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-10-01 | |||||
| タイトル | ||||||
| タイトル | Mitophagy reporter mouse analysis reveals increased mitophagy activity in disuse-induced muscle atrophy | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Shun-Ichi, Yamashita
× Shun-Ichi, Yamashita× Kyuuma, Masanao× Inoue, Keiichi× Hata, Yuki× Kawada,, Ryu× Yamabi, Masaki× Fujii, Yasuyuki× Sakagami, Junko× Fukuda, Tomoyuki× Furukawa, Kentaro× Satoshi, Tsukamoto× Kanki, Tomotake× Satoshi, Tsukamoto |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Muscle disuse induces atrophy through increased reactive oxygen species (ROS) released from damaged mitochondria. Mitophagy, the autophagic degradation of mitochondria, is associated with increased ROS production. However, the mitophagy activity status during disuse-induced muscle atrophy has been a subject of debate. Here, we developed a new mitophagy reporter mouse line to examine how disuse affected mitophagy activity in skeletal muscles. Mice expressing tandem mCherry-EGFP proteins on mitochondria were then used to monitor the dynamics of mitophagy activity. The reporter mice demonstrated enhanced mitophagy activity and increased ROS production in atrophic soleus muscles following a 14-day hindlimb immobilization. Results also showed an increased expression of multiple mitophagy genes, including Bnip3, Bnip3l, and Park2. Our findings thus conclude that disuse enhances mitophagy activity and ROS production in atrophic skeletal muscles and suggests that mitophagy is a potential therapeutic target for disuse-induced muscle atrophy. | |||||
| 書誌情報 |
Journal of Cellular Physiology 巻 236, 号 11, p. 7612-7624, 発行日 2021-05 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0021-9541 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1002/jcp.30404 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://onlinelibrary.wiley.com/doi/abs/10.1002/jcp.30404 | |||||
