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Initial results of a mouse brain PET insert with a staggered 3-layer DOI detector

https://repo.qst.go.jp/records/84716
https://repo.qst.go.jp/records/84716
34364475-1796-4bdc-808c-8f863ffeb9c7
Item type 学術雑誌論文 / Journal Article(1)
公開日 2021-11-06
タイトル
タイトル Initial results of a mouse brain PET insert with a staggered 3-layer DOI detector
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 Kang, Hangyu

× Kang, Hangyu

WEKO 1046471

Kang, Hangyu

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Hideaki, Tashima

× Hideaki, Tashima

WEKO 1046472

Hideaki, Tashima

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Fumihiko, Nishikido

× Fumihiko, Nishikido

WEKO 1046473

Fumihiko, Nishikido

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Go, Akamatsu

× Go, Akamatsu

WEKO 1046474

Go, Akamatsu

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Hidekatsu, Wakizaka

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WEKO 1046475

Hidekatsu, Wakizaka

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Makoto, Higuchi

× Makoto, Higuchi

WEKO 1046476

Makoto, Higuchi

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Taiga, Yamaya

× Taiga, Yamaya

WEKO 1046477

Taiga, Yamaya

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Kang, Hangyu

× Kang, Hangyu

WEKO 1046478

en Kang, Hangyu

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Hideaki, Tashima

× Hideaki, Tashima

WEKO 1046479

en Hideaki, Tashima

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Fumihiko, Nishikido

× Fumihiko, Nishikido

WEKO 1046480

en Fumihiko, Nishikido

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Go, Akamatsu

× Go, Akamatsu

WEKO 1046481

en Go, Akamatsu

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Hidekatsu, Wakizaka

× Hidekatsu, Wakizaka

WEKO 1046482

en Hidekatsu, Wakizaka

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Makoto, Higuchi

× Makoto, Higuchi

WEKO 1046483

en Makoto, Higuchi

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Taiga, Yamaya

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WEKO 1046484

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抄録
内容記述タイプ Abstract
内容記述 Small animal positron emission tomography (PET) requires a submillimeter resolution for better quantification of radiopharmaceuticals. On the other hand, depth-of-interaction (DOI) information is essential to preserve the spatial resolution while maintaining the sensitivity. Recently, we developed a staggered 3-layer DOI detector with 1 mm crystal pitch and 15 mm total crystal thickness, but we did not demonstrate the imaging performance of the DOI detector with full ring geometry. In this study we present initial imaging results obtained for a mouse brain PET prototype developed with the staggered 3-layer DOI detector. The prototype had 53 mm inner diameter and 11 mm axial field-of-view. The PET scanner consisted of 16 DOI detectors each of which had a staggered 3-layer LYSO crystal array (4/4/7 mm) coupled to a 4×4 SiPM array. The physical performance was evaluated in terms of the NEMA NU 4 2008 protocol. The measured spatial resolutions at the center and 15 mm radial offset were 0.67 mm and 1.56 mm for filtered-back-projection, respectively. The peak absolute sensitivity of 0.74% was obtained with an energy window of 400-600 keV. The resolution phantom imaging results show the clear identification of a submillimetric rod pattern with the ordered-subset expectation maximization algorithm. The inter-crystal scatter rejection using a narrow energy window could enhance the resolvability of a 0.75 mm rod significantly. In an animal imaging experiment, the detailed mouse brain structures such as cortex and thalamus were clearly identified with high contrast. In conclusion, we successfully developed the mouse brain PET insert prototype with a staggered 3-layer DOI detector.
書誌情報 Physics in Medicine & Biology

巻 66, 号 21, p. 210515, 発行日 2021-11
出版者
出版者 IOP Publishing
ISSN
収録物識別子タイプ ISSN
収録物識別子 0031-9155
PubMed番号
識別子タイプ PMID
関連識別子 34666328
DOI
識別子タイプ DOI
関連識別子 10.1088/1361-6560/ac311c
関連サイト
識別子タイプ URI
関連識別子 https://iopscience.iop.org/article/10.1088/1361-6560/ac311c
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