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  1. 原著論文

Nanoprobe-Based Magnetic Resonance Imaging of Hypoxia Predicts Responses to Radiotherapy, Immunotherapy, and Sensitizing Treatments in Pancreatic Tumors

https://repo.qst.go.jp/records/84708
https://repo.qst.go.jp/records/84708
8fddd682-b373-4bb7-bf10-92469dc39c2a
Item type 学術雑誌論文 / Journal Article(1)
公開日 2021-11-13
タイトル
タイトル Nanoprobe-Based Magnetic Resonance Imaging of Hypoxia Predicts Responses to Radiotherapy, Immunotherapy, and Sensitizing Treatments in Pancreatic Tumors
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 Liu, Jing

× Liu, Jing

WEKO 1022200

Liu, Jing

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Cabral, Horacio

× Cabral, Horacio

WEKO 1022201

Cabral, Horacio

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Song, Bin

× Song, Bin

WEKO 1022202

Song, Bin

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Ichio, Aoki

× Ichio, Aoki

WEKO 1022203

Ichio, Aoki

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Chen, Zhouyun

× Chen, Zhouyun

WEKO 1022204

Chen, Zhouyun

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Nishiyama, Nobuhiro

× Nishiyama, Nobuhiro

WEKO 1022205

Nishiyama, Nobuhiro

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Huang, Yuan

× Huang, Yuan

WEKO 1022206

Huang, Yuan

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Kataoka, Kazunori

× Kataoka, Kazunori

WEKO 1022207

Kataoka, Kazunori

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Mi, Peng

× Mi, Peng

WEKO 1022208

Mi, Peng

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Ichio, Aoki

× Ichio, Aoki

WEKO 1022209

en Ichio, Aoki

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抄録
内容記述タイプ Abstract
内容記述 Accurate diagnosis of tumors and predicting the therapeutic responses are highly demanded in the clinic to improve the treatment efficacy and survival rates. Since hypoxia develops in the progression of tumors and inversely correlates with prognosis and promotes resistance to radiotherapies and immunotherapies, it is a potential marker for therapeutic prediction. Therefore, effective discrimination of tumor hypoxia for predicting therapeutic outcomes is critical. Here, a magnetic resonance imaging (MRI)-based diagnosis strategy using contrast-amplifying nanoprobes that sense tumor acidosis and real-time observation of hypoxic conditions in tumors has been developed, aiming at accurate detection of pancreatic tumors and prediction of therapeutic effects. Our approach selectively probed xenograft, allograft, and transgenic spontaneous models of intractable pancreatic cancer, which lacks standardized predictive markers to identify patients who benefit most from treatments, and effectively discriminated the intratumoral hypoxia levels. By stratification of pancreatic tumors based on quantitative MR imaging of hypoxia, it enabled prediction of the responses to radiotherapy and immune checkpoint inhibitors. Moreover, the nanoprobe-based MRI could monitor hypoxia reduction by tumor normalization treatments, which permits visualizing pancreatic tumors that will respond to immune checkpoint blockade therapy, enhancing the response rate. The results demonstrate the potential of our strategy for accurate tumor diagnosis, patient stratification, and effective therapy.
書誌情報 ACS Nano

巻 15, 号 8, p. 13526-13538, 発行日 2021-08
ISSN
収録物識別子タイプ ISSN
収録物識別子 1936-0851
DOI
識別子タイプ DOI
関連識別子 10.1021/acsnano.1c04263
関連サイト
識別子タイプ URI
関連識別子 https://pubs.acs.org/doi/10.1021/acsnano.1c04263
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