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An Enriched Environment Alters DNA Repair and Inflammatory Responses After Radiation Exposure
https://repo.qst.go.jp/records/84429
https://repo.qst.go.jp/records/84429eb832f1c-7e67-4954-be10-968892f03606
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-10-24 | |||||
| タイトル | ||||||
| タイトル | An Enriched Environment Alters DNA Repair and Inflammatory Responses After Radiation Exposure | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Sakama, Sae
× Sakama, Sae× Kurusu, Keisuke× Morita, Mayu× Oizumi, Takashi× Masugata, Shinya× Oka, Shohei× Shinya, Yokomizo× Mayumi, Nishimura× Takamitsu, Morioka× Shizuko, Kakinuma× Yoshiya, Shimada× J. Nakamura, Asako× Shinya, Yokomizo× Mayumi, Nishimura× Takamitsu, Morioka× Shizuko, Kakinuma× Yoshiya, Shimada |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | After the Fukushima Daiichi Nuclear Power Plant accident, there is growing concern about radiation-induced carcinogenesis. In addition, living in a long-term shelter or temporary housing due to disasters might cause unpleasant stress, which adversely affects physical and mental health. It’s been experimentally demonstrated that “eustress”, which is rich and comfortable, has beneficial effects for health using mouse models. In a previous study, mice raised in the enriched environment (EE) has shown effects such as suppression of tumor growth and enhancement of drug sensitivity during cancer treatment. However, it’s not yet been evaluated whether EE affects radiation-induced carcinogenesis. Therefore, to evaluate whether EE suppresses a radiation-induced carcinogenesis after radiation exposure, in this study, we assessed the serum leptin levels, radiation-induced DNA damage response and inflammatory response using the mouse model. In brief, serum and tissues were collected and analyzed over time in irradiated mice after manipulating the raising environment during the juvenile or adult stage. To assess the radiation-induced DNA damage response, we performed immunostaining for phosphorylated H2AX which is a marker of DNA double-strand break. Focusing on the polarization of macrophages in the inflammatory reaction that has an important role in carcinogenesis, we performed analysis using tissue immunofluorescence staining and RT-qPCR. Our data confirmed that EE breeding before radiation exposure improved the responsiveness to radiation-induced DNA damage and basal immunity, further suppressing the chronic inflammatory response, and that might lead to a reduction of the risk of radiation-induced carcinogenesis. |
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| 書誌情報 |
Frontiers in Immunology 巻 12, p. 760322, 発行日 2021-10 |
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| 出版者 | ||||||
| 出版者 | Frontiers Media | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1664-3224 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.3389/fimmu.2021.760322 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.frontiersin.org/articles/10.3389/fimmu.2021.760322/full | |||||
