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Core excitation of phthalocyanine by X-irradiation to deep tissue targets of photoimmuno-therapy
https://repo.qst.go.jp/records/84376
https://repo.qst.go.jp/records/843763547728a-6124-4ee5-a0a3-20d835b5c44d
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-12-17 | |||||
| タイトル | ||||||
| タイトル | Core excitation of phthalocyanine by X-irradiation to deep tissue targets of photoimmuno-therapy | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Yudai, Izumi
× Yudai, Izumi× Maki, Ohara× Kentaro, Fujii× Akinari, Yokoya× Ritsuko, Yokoya× Keiichi, Nakagawa× Osamu, Inanami× Tetsuya, Taketsugu× Mikako, Ogawa× Yudai, Izumi× Maki, Ohara× Kentaro, Fujii× Akinari, Yokoya× Ritsuko, Yokoya |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Photoimmuno-therapy (PIT) has been recognized as one of the most promising methods in advanced cancer therapies. The technique applies photosensitizing molecules, particularly phthalocyanine (IR700), conjugated to monoclonal antibodies (mAbs) targeting epidermal growth factor receptors (EGFR) of cancer cell membranes. After irradiating the mAb-IR700-bound target cells with near-infrared (NIR) light, the axial ligands are released from the photosensitizers and, thereby, the cell membranes become brittle resulting prompt cell death. Although the evidences clearly show a strong potential of PIT, the practical penetration depth of NIR is less than a few cm and this might be controversial when it is applied to other deeply located tumors. To overcome this, we have examined X-ray induced core level excitation as alternative initiation probes. X-rays further penetrate in tissues than NIR. In the present study, the reaction probability of phthalocyanine with X-rays were evaluated by measuring atom selective K-shell X-ray absorption/excitation spectrum of IR700 using a synchrotron soft X-ray beamline. The cross sections of nitrogen (N), oxygen (O), and silicon (Si) atoms were evaluated using X-ray absorption fine structure (XANES) spectra, and reveled that O K-shell resonance excitation showed a larger cross section than those for N or Si, 2 hold of that at just below K-edge energy. This could be effective to detach the axial ligands because the oxygen atoms link the ligands and molecular body. Monte Carlo track simulation was applied to estimate the range of photo- and Auger electrons emitted by the K-excitation/ionization.Low energy Auger electrons showed noticeably short ranges less than a few ten nanometer and gave their energy within the molecular size of phthalocyanine. These results indicate that these secondary electrons may also contribute to the ligand release. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Pacifichem 2021 | |||||
| 発表年月日 | ||||||
| 日付 | 2021-12-21 | |||||
| 日付タイプ | Issued | |||||
