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Dose-Averaged LET Evaluation in Head and Neck Adenoid Cystic Carcinoma Patients for Carbon-Ion Radiotherapy
https://repo.qst.go.jp/records/84351
https://repo.qst.go.jp/records/84351a5823de3-0da9-49ac-ac01-93b355f1d765
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-12-21 | |||||
| タイトル | ||||||
| タイトル | Dose-Averaged LET Evaluation in Head and Neck Adenoid Cystic Carcinoma Patients for Carbon-Ion Radiotherapy | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Ryosuke, Kohno
× Ryosuke, Kohno× Sung-Hyun, Lee× Atsushi, Yamamoto× Keisi, Yamaoka× Makito, Suga× Masashi, Koto× Ryosuke, Kohno× Sung-Hyun, Lee× Atsushi, Yamamoto× Keisi, Yamaoka× Makito, Suga× Masashi, Koto |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose: In carbon ion radiation therapy (CIRT), the dose-averaged LET (LETd) is one of the important factors in determining clinical outcomes. In order to investigate the local control of adenoid cystic carcinoma (ACC) and the optic neuropathy of optic nerve (ON)s in CIRT, the effects of the LETd were evaluated clinically. We propose novel tumor control probability (TCP) and normal tissue complication probability (NTCP) models with D90-value of RBE-weighted dose and LETd as clinical parameters. Methods and Materials: Total 99 patients with head and neck ACC who received CIRT at the National Institute of Radiological Sciences were investigated. The physical dose and LETd distributions for each patient were recalculated using in-house treatment planning system. For ACC tumor, minimum-value of dose-averaged LET and D90-value of RBE-weighted dose as an indicator of evaluation were estimated. For ONs, maximum-value of LETd and maximum-value of RBE-weighted dose were evaluated. Results: For each prescribed RBE-weighted dose of 57.6 and 64 Gy (RBE), no statistical significance for local control by RBE-weighted dose was found, but for 64 Gy (RBE), we observed the LETd may be a marginally significant. For ONs, it was obvious that the optic neuropathy had a greater effect from RBE-weighted dose rather than dose-averaged LET. The proposed models could be applied to both TCP and NTCP prediction, and was found that the clinical outcomes from low to high LETd region were predictable. Conclusions: We analysed clinically the physical dose and LETd distributions for 99 patients with head and neck ACC. Our results indicated that LETd may be a determining factor for local control for ACC tumors. For ON, it was obvious that the RBE-weighted dose was related to optic neuropathy rather than LETd. The proposed approach may be helpful to predict whether LETd will affect clinical outcomes and be useful when constraining not only RBE-weighted dose but also LETd. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | AAPM2021 | |||||
| 発表年月日 | ||||||
| 日付 | 2021-07-25 | |||||
| 日付タイプ | Issued | |||||
