WEKO3
アイテム
Functional and molecular characterization of a non-human primate model of autism spectrum disorder shows similarity with the human disease
https://repo.qst.go.jp/records/84087
https://repo.qst.go.jp/records/84087abd9a4c7-549b-4f4f-b073-976efe21970b
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-09-17 | |||||
| タイトル | ||||||
| タイトル | Functional and molecular characterization of a non-human primate model of autism spectrum disorder shows similarity with the human disease | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Watanabe, Satoshi
× Watanabe, Satoshi× Kurotani, Tohru× Oga, Tomofumi× Noguchi, Jun× Isoda, Risa× Nakagami, Akiko× Sakai, Kazuhisa× Nakagaki, Keiko× Sumida, Kayo× Hoshino, Kohei× Saito, Koichi× Miyawaki, Izuru× Sekiguchi, Masayuki× Wada, Keiji× Takafumi, Minamimoto× Noritaka, Ichinohe× Takafumi, Minamimoto× Noritaka, Ichinohe |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Autism spectrum disorder (ASD) is a multifactorial disorder with characteristic synaptic and gene expression changes. Early intervention during childhood is thought to benefit prognosis. Here, we examined the changes in cortical synaptogenesis, synaptic function, and gene expression from birth to the juvenile stage in a marmoset model of ASD induced by valproic acid (VPA) treatment. Early postnatally, synaptogenesis was reduced in this model, while juvenile-age VPA-treated marmosets showed increased synaptogenesis, similar to observations in human tissue. During infancy, synaptic plasticity transiently increased and was associated with altered vocalization. Synaptogenesis-related genes were downregulated early postnatally. At three months of age, the differentially expressed genes were associated with circuit remodeling, similar to the expression changes observed in humans. In summary, we provide a functional and molecular characterization of a non-human primate model of ASD, highlighting its similarity to features observed in human ASD. | |||||
| 書誌情報 |
Nature Communications 巻 12, p. 5388, 発行日 2021-09 |
|||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2041-1723 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 34526497 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1038/s41467-021-25487-6 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.nature.com/articles/s41467-021-25487-6 | |||||
