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Proton-Cluster-Beam Lethality and Mutagenicity in Bacillus subtilis Spores
https://repo.qst.go.jp/records/84020
https://repo.qst.go.jp/records/840206906be2e-def7-42bf-b8bb-62947cb6b436
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-04-16 | |||||
| タイトル | ||||||
| タイトル | Proton-Cluster-Beam Lethality and Mutagenicity in Bacillus subtilis Spores | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Yoshihiro, Hase
× Yoshihiro, Hase× Katsuya, Sato× Atsuya, Chiba× Yoshimi, Hirano× Kengo, Moribayashi× Kazumasa, Narumi× Yoshihiro, Hase× Katsuya, Sato× Atsuya, Chiba× Yoshimi, Hirano× Kengo, Moribayashi× Kazumasa, Narumi |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The unique energy transfer characteristics of swift cluster ions have attracted the attention of many researchers working on the analysis or processing of material surfaces, but the effects on living organisms remain unclear. We irradiated B. subtilis spores with monomer and cluster proton beams and examined their lethality; the 2-MeV H2+ shows a clearly lower lethality than 340-keV H+, even though both have a comparable linear energy transfer. The 2-MeV H2+ dissoci-ates into a pair of 1-MeV H+ by losing the bonding electrons at the target surface. The estimated internuclear distance and the radial dose distribution suggest that the spread of deposited total energy over two areas separated by just several nanometers greatly diminishes beam lethality, and that the energy density in the very center of the trajectory, possibly within a 1-nm radius, has a great impact on lethality. We also performed a whole genome resequencing of the surviv-ing colonies to compare the molecular nature of mutations but failed to find a clear difference in overall characteristics. Our results suggest that cluster beams may be a useful tool for under-standing biological effects of high linear energy transfer radiation. | |||||
| 書誌情報 |
Quantum Beam Science 巻 5, 号 3, p. 25, 発行日 2021-08 |
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| 出版者 | ||||||
| 出版者 | MDPI | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2412-382X | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.3390/qubs5030025 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.mdpi.com/2412-382X/5/3/25 | |||||
