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Design and development of the molecular probes for application of the hyperpolarized-NMR/MRI
https://repo.qst.go.jp/records/83950
https://repo.qst.go.jp/records/8395050b63aa0-c62a-4c2e-9a2c-4b86a34417f0
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-10-13 | |||||
| タイトル | ||||||
| タイトル | Design and development of the molecular probes for application of the hyperpolarized-NMR/MRI | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Yoichi, Takakusagi
× Yoichi, Takakusagi× Yoichi, Takakusagi |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Hyperpolarized-nuclear magnetic resonance and imaging (HP-NMR/MRI) is a promising technique that allows direct monitoring of metabolic reactions in vitro and in vivo. Given the 13C- or 15N-labeled molecular probes whose NMR signal is amplified by the dynamic nuclear polarization (DNP) under a cryogenic magnetic field (3.35T, 1.4K), the sample is rapidly dissolved with a superheated solvent (~458 K), and then quickly reacted with enzymes or cells, or administered in animals put into the magnet. The metabolic reaction is readout onto the NMR spectra or MR image based on the >10,000-fold enhanced signals. By elucidating the extent of the metabolic reaction of the probes, early detection of disease-specific elevation of enzymatic activity, metabolic reprogramming, and alteration of their flux upon the treatment is possible. The development of various molecular probes will be a key factor to expand the utility of this approach. In this presentation, we will concisely introduce the basics of the dis-DNP, design and application of our recent new molecular probes that allow in vitro and in vivo HP-NMR/MRI. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | The 24th International Spin Symposium (SPIN2021) | |||||
| 発表年月日 | ||||||
| 日付 | 2021-10-19 | |||||
| 日付タイプ | Issued | |||||
