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Disentangling the Effects of Histone Post-Translational Modifications on Nucleosome Packing and Chromatin Structure.
https://repo.qst.go.jp/records/83937
https://repo.qst.go.jp/records/8393731224de4-553f-4e57-bfa8-46224e29ed71
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-11-02 | |||||
| タイトル | ||||||
| タイトル | Disentangling the Effects of Histone Post-Translational Modifications on Nucleosome Packing and Chromatin Structure. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Soon Chan, Wai
× Soon Chan, Wai× Hidetoshi, Kono× Soon Chan, Wai× Hidetoshi, Kono |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | DNA carries the blueprint of life. The control of when and how much genetic information is expressed in cells is partly governed by epigenetics. Nucleosomes, involved in DNA packing, are the most common protein-DNA complexes in the eukaryotic genome. Post-translational modifications (PTMs) of nucleosome’s histones can affect the interactions between nucleosomes and change the chromatin’s structure. Although experimental data of contact frequency maps between nucleosomes (Hi-CO & Micro-C XL) and the locations of the PTMs (ChIP-seq) are available, we lack a method to disentangle and to study the effects of PTMs on chromatin structure. We propose to build a coarse-grained model that can capture the effects of PTMs on the packing of nucleosomes or chromatin structure. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第59回 日本生物物理学会年会 | |||||
| 発表年月日 | ||||||
| 日付 | 2021-11-25 | |||||
| 日付タイプ | Issued | |||||
