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Mutation of a single critical region in the IgV domain of butyrophilin 3 reveals that one BTN3 chain functions as a sensor and the other as a ligand for the sensing of prenyl pyrophosphates by Vγ2Vδ2 T cells
https://repo.qst.go.jp/records/83820
https://repo.qst.go.jp/records/83820f3fd8f7b-21c3-4803-9066-046c9f602277
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-08-31 | |||||
| タイトル | ||||||
| タイトル | Mutation of a single critical region in the IgV domain of butyrophilin 3 reveals that one BTN3 chain functions as a sensor and the other as a ligand for the sensing of prenyl pyrophosphates by Vγ2Vδ2 T cells | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
T. Morita, Craig
× T. Morita, Craig× A. Rhodes, David× H. Nada, Mohanad× Tanaka, Yoshimasa× Shun, Sakuraba× Wang, Hong× Shun, Sakuraba |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | γδ T cells expressing Vγ2Vδ2 TCRs play critical roles in human immunity to microbes and tumors. These cells are uniquely able to use their TCRs for pattern recognition to monitor phosphorylated metabolites in isoprenoid biosynthesis in a process requiring butyrophilin (BTN) 3A1 and BTN2A1. Metabolites are sensed by binding to the intracellular BTN3A1 B30.2 domain and requires the juxtamembrane coiled coil region. The role played by the extracellular domains (ECD) of BTN3 is unclear. To define the role of the ECD, surface IgV and IgC residues were mutagenized to alanine. Mutant BTN3A1 cDNAs were expressed in 293 T embryonic kidney cells lacking BTN3A1, -A2, and -A3, and the transfected cells pulsed with zoledronic acid and used to stimulate Vγ2Vδ2 T cells for CD107a surface expression. The effects of mutagenesis will be discussed in the presentation. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | The 9th International γδ T Cell Conference | |||||
| 発表年月日 | ||||||
| 日付 | 2021-11-05 | |||||
| 日付タイプ | Issued | |||||
