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First Demonstration of Rat Total-Body PET Imaging with 4-Layer DOI Information
https://repo.qst.go.jp/records/83622
https://repo.qst.go.jp/records/836227ac8964c-df35-40a4-9007-778244056d38
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-10-15 | |||||
| タイトル | ||||||
| タイトル | First Demonstration of Rat Total-Body PET Imaging with 4-Layer DOI Information | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Kang, Hangyu
× Kang, Hangyu× Kang, Hangyu |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Preclinical positron emission tomography (PET) has been playing an important role for new drug development. The quantification accuracy of radiopharmaceuticals inside living small animals (e.g. mouse or rat) is mainly determined by the sensitivity which can be increased by using a thick crystal and long axial FOV. However, the thick crystal and long axial FOV can cause significant parallax errors for small animal PET scanners. Therefore, last year, we developed a total-body small animal PET (TBSAP) with a 4-layer depth-of-interaction (DOI) detector to achieve high sensitivity (16.7%) while minimizing the parallax error. In this study, we present the initial in vivo imaging results of the TBSAP with various radiotracers. The TBSAP has the 155 mm ring diameter and 315.6 mm axial FOV. The TBSAP consists of 6 rings each of which has 10 DOI detectors. Each DOI detector has a 4-layer GSOZ crystal array which results in a 30 mm total thickness and 2.9 mm crystal pitch. Whole-body rat imaging was performed for 15 min without any bed motion. The PET images were reconstructed by using OSEM algorithm and shown by maximum intensity projection (MIP). The in vivo imaging results show a clear bone structure (NaF) and glucose metabolism of the rat brain (FDG). In conclusion, the whole-body rat images can be obtained without any bed motion with the TBSAP. In the future, we plan to use the TBSAP for ultralow activity imaging applications such as in vivo single cell tracking and in-beam small animal PET imaging using micro carbon ion beams. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 2021 Virtual IEEE Nuclear Science Symposium and Medical Imaging Conference | |||||
| 発表年月日 | ||||||
| 日付 | 2021-10-21 | |||||
| 日付タイプ | Issued | |||||
