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Effects on organelle-network in human cells by X-ray exposure
https://repo.qst.go.jp/records/83537
https://repo.qst.go.jp/records/835373cbd24de-370f-4f5d-88fa-9a6cdcc71c5f
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-09-18 | |||||
| タイトル | ||||||
| タイトル | Effects on organelle-network in human cells by X-ray exposure | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Tomoyuki, Saito
× Tomoyuki, Saito× Ami, Suzuki× Eri, Hirose× Akinari, Yokoya× Tomoyuki, Saito× Ami, Suzuki× Eri, Hirose× Akinari, Yokoya |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | In eukaryotic cells, various organelle cooperatively works to sustain the supply chain management of cellular products and an eminent recycle mechanism known as autophagy enables this circulation of products. The system keeps homeostasis concerning energy metabolisms for cell proliferation with a proper cell cycle as well as communication among the cells constituting an organ. These concerted multi-reactions among the “intracellular creatures” look conspicuously like ecological systems that exert robustness against internal or external perturbation. Radiation stress as one of external ones would temporarily disturb the micro-world ecosystem. Although much knowledge of radiation effects on mitochondria have been accumulated, effects on and responses of other organelle including endoplasmic reticula (ER) have not yet been explored. ER contacts to mitochondrial and exchange Ca2+ ions as a signal of TCA cycle activation or apoptosis induction. Another role is folding of proteins provided by ribosomes. The properly folded proteins are taken in the transport vesicles and then delivered at Golgi body. Radiation effects on this organelle-network have been addressed in our research project, particularly focusing on ER in the hub of the network. We applied fluorescent agents to stain ER or Golgi body as well as mitochondria. Less-toxic chemicals and staining conditions were determined to perform a long-term tracking of living cells. Distribution and morphological alterations of these organelles in human cells exposed to X-rays will be presented. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 日本放射線影響学会第64回大会 | |||||
| 発表年月日 | ||||||
| 日付 | 2021-09-22 | |||||
| 日付タイプ | Issued | |||||
