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Radio-adaptive response induced by the targeted cytoplasmic irradiation in normal human fibroblasts with X-ray microbeams via intracellular or intercellular responses
https://repo.qst.go.jp/records/83417
https://repo.qst.go.jp/records/83417d2320c2c-53e5-4b52-987d-72f59a266cc3
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-09-24 | |||||
| タイトル | ||||||
| タイトル | Radio-adaptive response induced by the targeted cytoplasmic irradiation in normal human fibroblasts with X-ray microbeams via intracellular or intercellular responses | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
鈴木, 雅雄
× 鈴木, 雅雄× 宇佐美, 徳子× 崔, 星× 藤森, 亮× 小藤, 昌志× Masao, Suzuki× Sei, Sai× Akira, Fujimori× Masashi, Koto |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Study using a microbeam can provide us very important scientific evidence to understand radio-biological responses induced by low-fluence irradiations. Especially, the study of such biological responses for low LET radiation can surely provide the critical information for evaluating risk such low-dose exposure as the accident of Fukushima Daiichi Nuclear Power Plants caused by the Great East Japan Earthquake. We have been studying biological effects using the microbeams and set up a hypothesis from the data as follows; “When cytoplasm of targeted cells are irradiated with low-LET radiations, unknown cellular response(s) is induced in the cell and in consequence the cell becomes protective to radiation damage (radio-adaptive response).” Targeted cytoplasmic irradiations with X-ray microbeams to normal human fibroblasts were carried out using the cell-irradiation system at Photon Factory, KEK. Briefly, we used the microbeam covering the areas of 30µm x 30µm in which the center was masked by the gold-made post of 22 micrometer in diameter. When cell nucleus was irradiated, we used the microbeams collimating the beam size of 10µm x 10µm. Cell death (0.092Gy) was examined with nuclear irradiation alone or cytoplasmic irradiation nuclear irradiation. Surviving fraction irradiated with all cell nuclei alone was 0.79, however it was rising to 0.97 when cytoplasm of all cells was irradiated beforehand. The result showed the same even if cytoplasmic irradiations were done randomly selected at 10%. There is evidence that radio-adaptive response is induced in the cells preirradiated to cytoplasm with the low-dose X rays via intracellular or intercellular responses. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 日本放射線影響学会第64回大会 | |||||
| 発表年月日 | ||||||
| 日付 | 2021-09-22 | |||||
| 日付タイプ | Issued | |||||
