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High relative biological effectiveness of 2 MeV fast neutrons for induction of medulloblastoma in Ptch1+/- mice with radiation-specific deletion on chromosome 13
https://repo.qst.go.jp/records/83065
https://repo.qst.go.jp/records/8306514e62bf9-8000-43f1-bcab-101d9ba01121
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-06-02 | |||||
| タイトル | ||||||
| タイトル | High relative biological effectiveness of 2 MeV fast neutrons for induction of medulloblastoma in Ptch1+/- mice with radiation-specific deletion on chromosome 13 | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Chizuru, Tsuruoka
× Chizuru, Tsuruoka× Mutsumi, Kaminishi× Mayumi, Shinagawa× Yi, Shang× Yoshiko, Amasaki× Yoshiya, Shimada× Shizuko, Kakinuma× Chizuru, Tsuruoka× Mutsumi, Kaminishi× Mayumi, Shinagawa× Yi, Shang× Yoshiko, Amasaki× Yoshiya, Shimada× Shizuko, Kakinuma |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Neutron radiation, a high linear energy transfer radiation, has a high relative biological effectiveness (RBE) for various endpoints. The age at exposure is an important modifier of the effects of radiation, including carcinogenesis, with infants being generally more radiosensitive. Ptch1+/– mice offer a unique experimental system for assessing radiation carcinogenesis, as they undergo the spontaneous development of medulloblastoma tumors in non-irradiated animals that lose their Ptch1+ allele, most frequently by a loss of heterozygosity (LOH) of chromosome 13 via recombination or non-disjunction (referred to as S-type tumors). In contrast, tumors occur in irradiated Ptch1+/– mice as a result of chromosome 13 LOH with an interstitial deletion (R-type), making spontaneous and radiation-induced tumors discernible. To elucidate the influence of age on the effect of fast neutrons, we irradiated Ptch1+/– mice with neutrons (mean energy, ~2 MeV) or γ-rays on embryonic day (E)14 and E17 and on postnatal day (P)1, 4, or 10 and classified the resulting medulloblastomas based on chromosome 13 aberrations. Instead of LOH, some tumors harbored mutations in their Ptch1+ gene via a non-irradiation-associated mechanism such as duplication, insertion, base substitution or deletion with microhomology-mediated end joining; thus, these tumors were classified as S-type. The RBE regarding the induction of R-type tumors was 12.9 (8.6, 17.2), 9.6 (6.9, 12.3), 21.5 (17.2, 25.8), and 7.1 (4.7, 9.5) (mean and 95% confidence interval) for mice irradiated on E14, E17, P1, and P4, respectively, with the highest value seen during the most active development of the tissue and P10 being completely resistant. Our results indicate that the developmental stage at exposure of the tissue influences the RBE of neutrons. | |||||
| 書誌情報 |
Radiation Research 巻 196, 号 2, p. 225-234, 発行日 2021-08 |
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| 出版者 | ||||||
| 出版者 | Allen Press | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0033-7587 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 34046685 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1667/RADE-20-00025.1 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://meridian.allenpress.com/radiation-research/article/196/2/225/465822/High-Relative-Biological-Effectiveness-of-2-MeV | |||||
