WEKO3
アイテム
Off-tumor IDO1 target engagements determine the cancer-immune set point and predict the immunotherapeutic efficacy
https://repo.qst.go.jp/records/83039
https://repo.qst.go.jp/records/83039870e3d6b-f2cc-4b88-a673-d3136cd9f7d4
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-05-10 | |||||
| タイトル | ||||||
| タイトル | Off-tumor IDO1 target engagements determine the cancer-immune set point and predict the immunotherapeutic efficacy | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Lin, Xie
× Lin, Xie× Kuan, Hu× Duo, Yanhong× Takashi, Shimokawa× Katsushi, Kumata× Zhang, Yiding× Jiang, Cuiping× Zhang, Lulu× Nobuki, Nengaki× Hidekatsu, Wakizaka× Cao, Yihai× Zhang, Ming-Rong× Lin, Xie× Kuan, Hu× Takashi, Shimokawa× Katsushi, Kumata× Zhang, Yiding× Nobuki, Nengaki× Hidekatsu, Wakizaka× Zhang, Ming-Rong |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background: Indoleamine-2,3-dioxygenase 1 (IDO1) has been intensively pursued as a therapeutic target to reverse the immunosuppressive cancer-immune milieu and promote tumor elimination. However, recent failures of phase III clinical trials with IDO1 inhibitors involved in cancer immunotherapies highlight the urgent need to develop appropriate methods for tracking IDO1 when the cancer-immune milieu is therapeutically modified. Methods: We utilized a small-molecule radiotracer, 11C-L-1MTrp, to quantitatively and longitudinally visualize whole-body IDO1 dynamics. Specifically, we firstly assessed 11C-L-1MTrp in mice bearing contralateral human tumors with distinct IDO1 expression patterns. Then, we applied 11C-L-1MTrp to longitudinally monitor whole-body IDO1 variations in immunocompetent melanoma-bearing mice treated with L-1MTrp plus either chemotherapeutic drugs or antibodies targeting PD-1 and CTLA4. Results: 11C-L-1MTrp positron emission tomography (PET) imaging accurately delineated IDO1 expression in xenograft mouse models. Moreover, we were able to visualize dynamic IDO1 regulation in the mesenteric lymph nodes (MLNs), an off-tumor IDO1 target, where the percentage uptake of 11C-L-1MTrp accurately annotated the therapeutic efficacy of multiple combination immunotherapies in preclinical models. Remarkably, 11C-L-1MTrp signal intensity in the MLNs was inversely related to the specific growth rates of treated tumors, suggesting that IDO1 expression in the MLNs can serve as a new biomarker of the cancer-immune set point. Conclusions: PET imaging of IDO1 with 11C-L-1MTrp is a robust method to assess the therapeutic efficacy of multiple combinatorial immunotherapies, improving our understanding of the merit and challenges of IDO1 regimens. Further validation of this animal data in humans is ongoing. We envision that our results will provide a potential precision medicine paradigm for noninvasive visualizing each patient's individual response in combinatorial cancer immunotherapy, and tailoring optimal personalized combination strategies. |
|||||
| 書誌情報 |
Journal for ImmunoTherapy of Cancer 巻 9, 号 6, p. e002616, 発行日 2021-05 |
|||||
| 出版者 | ||||||
| 出版者 | BMJ | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2051-1426 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1136/jitc-2021-002616 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://jitc.bmj.com/content/9/6/e002616 | |||||
