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Tau PET findings of chronic traumatic encephalopathy (CTE) and late-life psychiatric diseases
https://repo.qst.go.jp/records/82821
https://repo.qst.go.jp/records/8282143aeb2fb-2ef8-44c5-ad30-5c321c124813
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-05-13 | |||||
| タイトル | ||||||
| タイトル | Tau PET findings of chronic traumatic encephalopathy (CTE) and late-life psychiatric diseases | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Keisuke, Takahata
× Keisuke, Takahata× Keisuke, Takahata |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Tau PET is a molecular imaging technique to detect accumulation of tau aggregates in neurodegenerative diseases non-invasively using a specific probe for tau. Our previous clinical studies using 11C-PBB3 have shown that abundance of tau pathology in the focal brain region is associated with a variety of psychiatric symptoms, including psychotic symptoms in late-life depression (Moriguchi et al., 2020) and long-term psychiatric outcomes of traumatic brain injury (TBI) (Takahata et al., 2019). These studies suggest that tau pathology in the brain is associated with the development of psychiatric symptoms. However, first-generation tau PET tracers have several issues that impede practical application, such as non-specific accumulation in the venous sinus, off-target binding, low image contrast and metabolic instability. 18F- APN-1607(18F-PM-PBB3) is second-generation tau PET tracer, which is characterized by less non-specific accumulation, higher image contrast, and metabolic stability than first-generation tau PET tracers. Our recent study showed that PET imaging using this tracer can capture tau pathology not only in Alzheimer’s disease (AD) but also in a wide range of non-AD tauopathies (Tagai et al., 2020). Therefore, 18F- APN-1607 is expected to be a powerful tool for exploring the pathology underlying psychiatric diseases. In this lecture, we will show PET findings in a neurodegenerative disease due to TBI (chronic traumatic encephalopathy: CTE) with a focus on the case of boxers and late-life psychiatric disorders (late-life psychosis, late-life mood disorder). We also discuss techniques for accurate quantification of tau pathology using tau PET in chronic stage of TBI in consideration of unique topology of tau lesions in CTE. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | The 3rd Annual Workshop on APN-1607 (PM-PBB3) | |||||
| 発表年月日 | ||||||
| 日付 | 2020-12-11 | |||||
| 日付タイプ | Issued | |||||
