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Dynamic alterations in the central glutamatergic status following food and glucose intake: in vivo multimodal assessments in humans and animal models
https://repo.qst.go.jp/records/82681
https://repo.qst.go.jp/records/8268110e6cd63-c1fd-4a5d-945d-e46eb6440fc1
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-03-02 | |||||
| タイトル | ||||||
| タイトル | Dynamic alterations in the central glutamatergic status following food and glucose intake: in vivo multimodal assessments in humans and animal models | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Manabu, Kubota
× Manabu, Kubota× Yasuyuki, Kimura× Masafumi, Shimojo× Yuhei, Takado× M.N. Duarte, Joao× Hiroyuki, Takuwa× Chie, Seki× Hitoshi, Shimada× Hitoshi, Shinoto× Keisuke, Takahata× Soichiro, Kitamura× Sho, Moriguchi× Kenji, Tagai× Takayuki, Obata× Nakahara, Jin× Yutaka, Tomita× Masaki, Tokunaga× Jun, Maeda× Kazunori, Kawamura× Zhang, Ming-Rong× Masanori, Ichise× Tetsuya, Suhara× Makoto, Higuchi× Manabu, Kubota× Yasuyuki, Kimura× Masafumi, Shimojo× Yuhei, Takado× Hiroyuki, Takuwa× Chie, Seki× Hitoshi, Shimada× Hitoshi, Shinoto× Keisuke, Takahata× Soichiro, Kitamura× Sho, Moriguchi× Kenji, Tagai× Takayuki, Obata× Yutaka, Tomita× Masaki, Tokunaga× Jun, Maeda× Kazunori, Kawamura× Zhang, Ming-Rong× Masanori, Ichise× Tetsuya, Suhara× Makoto, Higuchi |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Fluctuations of neuronal activities in the brain may underlie relatively slow components of neurofunctional alterations, which can be modulated by food intake and related systemic metabolic statuses. Glutamatergic neurotransmission plays a major role in the regulation of excitatory tones in the central nervous system, although just how dietary elements contribute to the tuning of this system remains elusive. Here, we provide the first demonstration by bimodal positron emission tomography (PET) and magnetic resonance spectroscopy (MRS) that metabotropic glutamate receptor subtype 5 (mGluR5) ligand binding and glutamate levels in human brains are dynamically altered in a manner dependent on food intake and consequent changes in plasma glucose levels. The brain-wide modulations of central mGluR5 ligand binding and glutamate levels and profound neuronal activations following systemic glucose administration were further proven by PET, MRS, and intravital two-photon microscopy, respectively, in living rodents. The present findings consistently support the notion that food-associated glucose intake is mechanistically linked to glutamatergic tones in the brain, which are translationally accessible in vivo by bimodal PET and MRS measurements in both clinical and non-clinical settings. | |||||
| 書誌情報 |
Journal of Cerebral Blood Flow & Metabolism 巻 41, 号 11, p. 2928-2943, 発行日 2021-05 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0271-678X | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 34039039 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1177/0271678X211004150 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://journals.sagepub.com/doi/10.1177/0271678X211004150 | |||||
