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  1. 原著論文

Biodistribution and radiation dosimetry of the positron emission tomography probe for AMPA receptor, [11C]K-2, in healthy human subjects

https://repo.qst.go.jp/records/82637
https://repo.qst.go.jp/records/82637
660c468c-09bb-41a8-8b4d-f428765aa2e4
Item type 学術雑誌論文 / Journal Article(1)
公開日 2021-04-06
タイトル
タイトル Biodistribution and radiation dosimetry of the positron emission tomography probe for AMPA receptor, [11C]K-2, in healthy human subjects
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 Hatano, Mai

× Hatano, Mai

WEKO 1013019

Hatano, Mai

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Miyazaki, Tomoyuki

× Miyazaki, Tomoyuki

WEKO 1013020

Miyazaki, Tomoyuki

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Ishiwata, Yoshinobu

× Ishiwata, Yoshinobu

WEKO 1013021

Ishiwata, Yoshinobu

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Nakajima, Waki

× Nakajima, Waki

WEKO 1013022

Nakajima, Waki

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Arisawa, Tetsu

× Arisawa, Tetsu

WEKO 1013023

Arisawa, Tetsu

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Kuroki, Yoko

× Kuroki, Yoko

WEKO 1013024

Kuroki, Yoko

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Kobayashi, Ayako

× Kobayashi, Ayako

WEKO 1013025

Kobayashi, Ayako

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Takada, Yuuki

× Takada, Yuuki

WEKO 1013026

Takada, Yuuki

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Ogawa, Matsuyoshi

× Ogawa, Matsuyoshi

WEKO 1013027

Ogawa, Matsuyoshi

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Kazunori, Kawamura

× Kazunori, Kawamura

WEKO 1013028

Kazunori, Kawamura

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Ming‑Rong, Zhang

× Ming‑Rong, Zhang

WEKO 1013029

Ming‑Rong, Zhang

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Higuchi , Makoto

× Higuchi , Makoto

WEKO 1013030

Higuchi , Makoto

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MasatakaTaguri

× MasatakaTaguri

WEKO 1013031

MasatakaTaguri

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Kimura, Yasuyuki

× Kimura, Yasuyuki

WEKO 1013032

Kimura, Yasuyuki

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Takahashi, Takuya

× Takahashi, Takuya

WEKO 1013033

Takahashi, Takuya

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Tomoyuki, Miyazaki

× Tomoyuki, Miyazaki

WEKO 1013034

en Tomoyuki, Miyazaki

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Kazunori, Kawamura

× Kazunori, Kawamura

WEKO 1013035

en Kazunori, Kawamura

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Zhang, Ming-Rong

× Zhang, Ming-Rong

WEKO 1013036

en Zhang, Ming-Rong

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Makoto, Higuchi

× Makoto, Higuchi

WEKO 1013037

en Makoto, Higuchi

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Yasuyuki, Kimura

× Yasuyuki, Kimura

WEKO 1013038

en Yasuyuki, Kimura

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抄録
内容記述タイプ Abstract
内容記述 [11C]K-2, a radiotracer exhibiting high affinity and selectivity for α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs), is suitable for the quantification of AMPARs in living human brains and potentially useful in the identification of epileptogenic foci in patients. This study aimed to estimate the radiation doses of [11C]K-2 in various organs and calculate the effective dose after injection of [11C]K-2 in healthy human subjects. Twelve healthy male subjects were registered and divided into two groups (370 or 555 MBq of [11C]K-2), followed by 2 h whole-body scans. We estimated the radiation dose of each organ and then calculated the effective dose for each subject. The highest uptake of [11C]K-2 was observed in the liver, while the brain also showed relatively high uptake. The urinary bladder exhibited the highest radiation dose. The kidneys and liver also showed high radiation doses after [11C]K-2 injections. The effective dose of [11C]K-2 ranged from 5.0 to 5.2 μSv/MBq. Our findings suggest that [11C]K-2 is safe in terms of the radiation dose and adverse effects. The injection of 370–555 MBq (10 to 15 mCi) for PET studies using this radiotracer is applicable in healthy human subjects and enables serial PET scans in a single subject.
書誌情報 Scientific Reports

巻 11, 号 1, p. 1598, 発行日 2021-01
出版者
出版者 Nature
ISSN
収録物識別子タイプ ISSN
収録物識別子 2045-2322
PubMed番号
識別子タイプ PMID
関連識別子 33452361
DOI
識別子タイプ DOI
関連識別子 10.1038/s41598-021-81002-3
関連サイト
識別子タイプ URI
関連識別子 https://www.nature.com/articles/s41598-021-81002-3
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