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Novel 18F-labeled α-methyl-phenylalanine derivative with high tumor accumulation and ideal pharmacokinetics for tumor-specific imaging
https://repo.qst.go.jp/records/82621
https://repo.qst.go.jp/records/82621552100b7-8fbb-4571-9cc6-07f88751398b
| Item type | 一般雑誌記事 / Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-04-05 | |||||
| タイトル | ||||||
| タイトル | Novel 18F-labeled α-methyl-phenylalanine derivative with high tumor accumulation and ideal pharmacokinetics for tumor-specific imaging | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Yasuhiro, Oshima
× Yasuhiro, Oshima× Yasuhiro, Oshima |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Positron emission tomography (PET) with amino acid analogs has great impacts on the treatment of cancer by diagnosis, staging, and monitoring. Among them, 3-18F-fluoro-α-methyl-L-tyrosine (18F-FAMT) has been routinely used for tumor diagnosis in Gunma University Hospital. The specific accumulation of 18F-FAMT in malignant tumors is exclusively promoted by L-type amino acid transporter 1 (LAT1), the expression of which is highly upregulated in many types of cancers. However, a major drawback of 18F-FAMT PET is the relatively high frequency of false-negative results because of its low tumor accumulation level. These clinical findings have prompted the further development of 18F-FAMT analogs with higher tumor accumulation and improved pharmacokinetics. In this study, we prepared 18F-FAMP regioisomers (2-, 3-, or 4-18F-FAMP) and stereoisomers (L- or D-form), and we comprehensively evaluated their potential as tumor-imaging agents. | |||||
| 書誌情報 |
QST Takasaki Annual Report 2019 p. 16-16, 発行日 2021-03 |
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