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Neuroprotective effect of mitochondrial translocator protein ligand in a mouse model of tauopathy.
https://repo.qst.go.jp/records/82335
https://repo.qst.go.jp/records/82335af2bcc23-aebf-41a5-94bc-0222c9890738
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-03-22 | |||||
| タイトル | ||||||
| タイトル | Neuroprotective effect of mitochondrial translocator protein ligand in a mouse model of tauopathy. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
H Fairley, Lauren
× H Fairley, Lauren× Sahara, Naruhiko× Aoki, Ichio× Ji, Bin× Suhara, Tetsuya× Higuchi, Makoto× M Barron, Anna× Naruhiko, Sahara× Ichio, Aoki× Ji, Bin× Tetsuya, Suhara× Makoto, Higuchi |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The translocator protein (TSPO) has been identified as a positron emission tomography (PET)-visible biomarker of inflammation and promising immunotherapeutic target for the treatment of Alzheimer's disease (AD). While TSPO ligands have been shown to reduce the accumulation of the toxic Alzheimer's beta-amyloid peptide, their effect on tau pathology has not yet been investigated. To address this, we analyzed the effects of TSPO ligand, Ro5-4864, on the progression of neuropathology in rTg4510 tau transgenic mice (TauTg). | |||||
| 書誌情報 |
Journal of neuroinflammation 巻 18, 号 1, p. 76, 発行日 2021-03 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1742-2094 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 33740987 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1186/s12974-021-02122-1 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-021-02122-1 | |||||
