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Effect of longitudinal magnetic field to the linear particle-beam track on yields of hydroxyl radical and hydrogen peroxide in water
https://repo.qst.go.jp/records/82317
https://repo.qst.go.jp/records/82317d1ce8d23-45dc-48f2-9c46-b6a7abc0d227
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-12-27 | |||||
| タイトル | ||||||
| タイトル | Effect of longitudinal magnetic field to the linear particle-beam track on yields of hydroxyl radical and hydrogen peroxide in water | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Ken-ichiro, Matsumoto
× Ken-ichiro, Matsumoto× Nakanishi, Ikuo× Abe, Yasushi× Sato, Shinji× Muramatsu, Masayuki× Kohno, Ryosuke× Sakata, Dousatsu× Mizushima, Kota× Mizuno, Hideyuki× Inaniwa, Taku× Kenichiro, Matsumoto× Ikuo, Nakanishi× Yasushi, Abe× Shinji, Sato× Masayuki, Muramatsu× Ryosuke, Kohno× Dousatsu, Sakata× Kota, Mizushima× Hideyuki, Mizuno× Taku, Inaniwa |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The effect of a magnetic field loaded parallel to the ion-beam track on the generations of reactive oxygen species (ROS) in water was investigated. It was reported that loading magnetic field parallel to the particle beam track exaggerate the biological effects, i.e. cell lethality, of the particle beam. However, the mechanism of the enhanced cell death delivered by a logigudinal magnetic field to the beam track has not been clarified yet. Local density of •OH generation was estimated by a method based on EPR spin-trapping technique. A series of reaction mixtures containing varying concentrations (0.76‒2278 mM) of DMPO was prepared, and transferred to a polyethylene bag for irradiation. Then, the samples were irradiated 16 Gy of carbon- or iron-beam at the Heavy-Ion Medical Accelerator in Chiba (HIMAC, NIRS/QST, Chiba, Japan) with or without longitudinal magnetic field (0.0, 0.3, or 0.6 T). O2-dependent and O2-independent H2O2 yield was measured. An aliquot of ultra-pure water was irradiated by carbon-ion beam with or without longitudinal magnetic field. Irradiation experiments were performed under air or hypoxic (<0.5% oxygen) conditions. H2O2 generations in irradiated water samples were quantified by an EPR spin-trapping method, which measures •OH synthesized from H2O2 by the UVB irradiation. Relatively sparse •OH generations caused by particle beams in waster were not affected with loading magnetic field on beam track. Oxygen dependent H2O2 generation was decreased and oxygen-independent H2O2 generation was increased under loading magnetic field parallel to the beam track. Loading magnetic field parallel to the beam track could make •OH generation denser, or could make reaction of dense •OH increased. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 20th Biennial Meeting of SFRR International (SFRR-I 2021) | |||||
| 発表年月日 | ||||||
| 日付 | 2021-03-15 | |||||
| 日付タイプ | Issued | |||||
