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A potential renewed use of very heavy ions for therapy: Neon minibeam radiation therapy
https://repo.qst.go.jp/records/82287
https://repo.qst.go.jp/records/822876795a390-8c1d-4ca0-ad3a-458b5ea7d2a9
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-03-17 | |||||
| タイトル | ||||||
| タイトル | A potential renewed use of very heavy ions for therapy: Neon minibeam radiation therapy | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Prezado, Yolanda
× Prezado, Yolanda× Ryoichi, Hirayama× Naruhiro, Matsufuji× Taku, Inaniwa× I., Martinez-Rovira× Seksek, Olivier× Bertho, Annaig× Sachiko, Koike× Labiod, Dalila× Pouzoulet, Frederic× Polledo, Laura× Warfving, Nils× Liens, Alethea× Bergs, Judith× Takashi, Shimokawa× Prezado, Yolanda× Ryoichi, Hirayama× Naruhiro, Matsufuji× Taku, Inaniwa× Seksek, Olivier× Bertho, Annaig× Sachiko, Koike× Labiod, Dalila× Bergs, Judith× Takashi, Shimokawa |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | (1) Background: Among all types of radiation, very heavy ions, such as Neon (Ne) or Argon (Ar), are the optimum candidates for hypoxic tumor treatments due to their reduced oxygen enhance-ment effect. However, their pioneering clinical use in the 1970s was halted due to severe side effects. The aim of this work was to provide a first proof that the combination of very heavy ions with minibeam radiation therapy leads to a minimization of toxicities, and thus, opening the door for a renewed use of heavy ions for therapy; (2) Methods: Mouse legs were irradiated with either Ne MBRT or Ne broad beams at the same average dose. Skin toxicity was scored for a period of 4 weeks. Histopathology evaluations were carried out at the end of the study; (3) Results: A significant dif-ference in toxicity was observed between the two irradiated groups. While severe damage, in-cluding necrosis, was observed in the broad beam group, only light to mild erythema was present in the MBRT group; (4) Conclusion: Ne MBRT is significantly better tolerated than conventional broad beam irradiations. | |||||
| 書誌情報 |
Cancers 巻 13, 号 6, p. 1356, 発行日 2021-03 |
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| 出版者 | ||||||
| 出版者 | MDPI | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2072-6694 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.3390/cancers13061356 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.mdpi.com/2072-6694/13/6/1356 | |||||
