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Human SIRT2 and SIRT3 deacetylases function in DNA homologous recombinational repair
https://repo.qst.go.jp/records/82248
https://repo.qst.go.jp/records/82248d7c1fe26-8794-4ad3-8c92-63efe8cd0f61
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-03-18 | |||||
| タイトル | ||||||
| タイトル | Human SIRT2 and SIRT3 deacetylases function in DNA homologous recombinational repair | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Takeshi, Yasuda
× Takeshi, Yasuda× Kazuya, Takizawa× Ui, Ayako× Michio, Hama× Kagawa, Wataru× Sugasawa, Kaoru× Katsushi, Tajima× Takeshi, Yasuda× Kazuya, Takizawa× Michio, Hama× Katsushi, Tajima |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | SIRT2 and SIRT3 protein deacetylases maintain genome integrity and stability. However, their mechanisms for maintaining the genome remain unclear. To examine the roles of SIRT2 and SIRT3 in DSB repair, I‐SceI‐based GFP reporter assays for HR, single‐strand annealing (SSA), and non‐homologous end joining (NHEJ) repair were performed under SIRT2‐ or SIRT3‐depleted conditions. SIRT2 or SIRT3 depletion inhibited HR repair equally to RAD52 depletion, but did not affect SSA and NHEJ repairs. SIRT2 or SIRT3 depletion disturbed the recruitment of RAD51 to DSB sites, an essential step for RAD51‐dependent HR repair, but not directly through RAD52 deacetylation. SIRT2 or SIRT3 depletion decreased the colocalization of γH2AX foci with RPA1, and thus they might be involved in initiating DSB end resection for the recruitment of RAD51 to DSB sites at an early step in HR repair. These results reveal the novel underlying mechanism of the SIRT2 and SIRT3 functions in HR for genome stability. | |||||
| 書誌情報 |
Genes to Cells 巻 26, 号 5, p. 328-335, 発行日 2021-03 |
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| 出版者 | ||||||
| 出版者 | Wiley | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1356-9597 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1111/gtc.12842 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://onlinelibrary.wiley.com/doi/10.1111/gtc.12842 | |||||
