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Comparison of substitution velocity of multivalent metallic radionuclide coordinated with serum protein mixture by chelates using in vitro Fe(III) model
https://repo.qst.go.jp/records/82186
https://repo.qst.go.jp/records/82186aa447f6c-415a-42a1-860d-49e2b04dc453
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-12-11 | |||||
| タイトル | ||||||
| タイトル | Comparison of substitution velocity of multivalent metallic radionuclide coordinated with serum protein mixture by chelates using in vitro Fe(III) model | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Izumi, Tanaka
× Izumi, Tanaka× Hiroshi, Ishihara× Akihiro, Uehara× Mika, Tanaka× Kazuko, Yokochi× Shino, Takeda× Izumi, Tanaka× Hiroshi, Ishihara× Akihiro, Uehara× Mika, Tanaka× Kazuko, Yokochi× Shino, Takeda |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Actinoids are transition metallic radionuclides and the most of them are stable in the oxidation state at trivalent and tetravalent. When they penetrate into animal body, they coordinate with endogenous ligand in interstitial (extracellular) fluid, and stagnate in the infiltrated tissue. After the ligand substituted with migrative serum proteins that possess affinity with multivalent metal cation such as transferrin, they are translocated to circulation and dispersed whole body. A chelating agent, diethylenetriaminepentaacetate (DTPA) is used for internal decorporation therapy. The first process of the action mechanism of the chelating agent is that the injected DTPA molecule captures multivalent metal cation from bioorganic ligand. Subsequently, resulted stable chelate coordinated with metal translocates urinary excretion system. However, the practical chelate action is far complicated because the interstitial fluid in the body contains various bioorganic ligands which react with multivalent metal cation and chelate, and the coordination compounds affect on the bind-dissociation reaction each other. The biochemical data on reaction velocity using the interstitial fluid are necessary or more accurate estimation of the effect of chelate treatment on the committed effective dose in organ following internal exposure of tri-/tetravalent radionuclide. We studied metal substitution from serum proteins to chelate using Fe(III) model. 59Fe-bound serum prepared from mouse was treated in physiological condition with DTPA, ethylenediaminetetraacetate, or deferoxamine. The substitution velocity, obtained by the measurement of the amounts of chelate-59Fe and protein-59Fe after the separation by isoelectric focusing electrophoresis, were consistent with decorporation experiments in mice. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 日本放射線影響学会第63回大会 | |||||
| 発表年月日 | ||||||
| 日付 | 2020-10-15 | |||||
| 日付タイプ | Issued | |||||
