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Multimodal Functional Imaging for Cancer/Tumor Microenvi-ronments based on MRI, EPRI, and PET
https://repo.qst.go.jp/records/82119
https://repo.qst.go.jp/records/82119def28cbc-eb2e-4d70-90fe-a644f3a7dc80
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Matsumoto.K.2021.Molecules.26(6).1614.pdf (12.7 MB)
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| Item type | 一般雑誌記事 / Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-01-20 | |||||
| タイトル | ||||||
| タイトル | Multimodal Functional Imaging for Cancer/Tumor Microenvi-ronments based on MRI, EPRI, and PET | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | article | |||||
| 著者 |
Ken-ichiro, Matsumoto
× Ken-ichiro, Matsumoto× B. Mitchell, James× C. Krishna, Murali× Kenichiro, Matsumoto |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Radiation therapy is one of the main modalities to treat cancer/tumor. The response to radiation therapy, however, can be influenced by physiological and/or pathological conditions in the target tissues, especially by the low partial oxygen pressure and altered redox status in cancer/tumor tissues. Visualizing such cancer/tumor patho-physiological microenvironment would be a useful not only for planning radiotherapy but also to detect cancer/tumor in an earlier stage. Tumor hypoxia could be sensed by positron emission tomography (PET), electron paramagnetic resonance (EPR) oxygen mapping, and in vivo dynamic nuclear polarization (DNP) MRI. Tissue oxygenation could be visualized on a real-time basis by blood oxygen level dependent (BOLD) and/or tissue oxygen level dependent (TOLD) MRI signal. EPR imaging (EPRI) and/or T1-weighted MRI techniques can visualize tissue redox status non-invasively based on paramagnetic and dia-magnetic conversions of nitroxyl radical contrast agent. 13C-DNP MRI can visualize glycometabolism of tumor/cancer tissues. Accurate co-registration of those multimodal images could make mechanisms of drug and/or relation of resulted biological effects clear. A multimodal instrument, such as PET-MRI, may have another possibility to link multiple functions. Functional imaging techniques individually developed to date have being converged on the concept of theranostics. | |||||
| 書誌情報 |
Molecules 巻 26, 号 6, p. 1614, 発行日 2021-03 |
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| 出版者 | ||||||
| 出版者 | MDPI publisher | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1420-3049 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.mdpi.com/1420-3049/26/6/1614 | |||||
