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Characterization and clinical significance of the CADM1/HER2/STAT3 axis in serous ovarian tumors
https://repo.qst.go.jp/records/82047
https://repo.qst.go.jp/records/820473c25f23a-6517-4a0b-9ad3-fbd39ecf6063
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-11-19 | |||||
| タイトル | ||||||
| タイトル | Characterization and clinical significance of the CADM1/HER2/STAT3 axis in serous ovarian tumors | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Wu, Dan
× Wu, Dan× Lei, Yuzhou× Liu, Qin× Hu, Hua× Li, Huanhuan× Xie, Lin× Zhou, Jianbin× Lin, Xie |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Objective: The subtypes of serous ovarian tumors (SOTs), including benign serous cystadenoma, serous borderline tumor (SBT), low-grade serous carcinoma (LGSC), and high-grade serous carcinoma (HGSC), remain poorly understood. Herein, we aimed to characterize the cell adhesion molecule 1 (CADM1)/signal transducer and activator of transcription 3 (STAT3)/human epidermal growth factor receptor 2 (HER2) axis and identify its clinical significance in patients with serous cystadenoma, SBT, LGSC, and HGSC. Methods: The immunohistochemical expression of CADM1, HER2, and STAT3 was assessed in 180 SOT specimens, and its association with clinical data was determined. Results: High levels of CADM1 expression were detected in 100% of serous cystadenomas and 83.33% of SBTs, while a loss of CADM1 expression was observed in 44% of LGSCs and 72.5% of HGSCs. Relative to the levels in benign cystadenomas and SBTs, higher levels of HER2 and STAT3 expression were observed in LGSCs and aggressive HGSCs. Furthermore, the expression profile of the CADM1/HER2/STAT3 axis was significantly associated with histologic type, International Federation of Gynecology and Obstetrics stage, and lymph node metastasis in patients with SOT. Conclusions: Our study identified the changes in the CADM1/HER2/STAT3 axis that were closely associated with the clinical behavior of SOTs. These molecular data may provide new insights into SOT carcinogenesis and aid in the diagnosis and treatment of patients with SOT. Keywords: cell adhesion molecule 1, human epidermal growth factor receptor 2, signal transducer and activator of transcription 3, serous ovarian tumor |
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| 書誌情報 |
Medicine 巻 100, 号 8, p. e23777, 発行日 2020-11 |
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| 出版者 | ||||||
| 出版者 | Wolters Klumer | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0025-7974 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1097/MD.0000000000023777 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://journals.lww.com/md-journal/Fulltext/2021/02260/Characterization_and_clinical_significance_of_the.3.aspx | |||||
