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Fabrication of gold nanohybrids modified with antibody and functional dendrimers for targeted photothermal theranostics
https://repo.qst.go.jp/records/81936
https://repo.qst.go.jp/records/819362371a8ec-0bb6-42a3-845a-a4dd30d9305e
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-02-21 | |||||
| タイトル | ||||||
| タイトル | Fabrication of gold nanohybrids modified with antibody and functional dendrimers for targeted photothermal theranostics | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Setiawan, Herlan
× Setiawan, Herlan× Yuba, Eiji× Harada, Atsushi× Ichio, Aoki× Kono, Kenji× Ichio, Aoki |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Targeted theranostics can improve benefits of therapeutics or imaging probes by minimizing the dose and by selective delivery to a target site. For this study, a gold nanorod (AuNR)‐based nanohybrid was designed for efficient cancer treatment and diagnosis. The AuNR was functionalized with polyamidoamine dendrimers having poly(ethylene glycol) and Gd‐DOTA residues to provide biocompatibility and magnetic resonance (MR) imaging properties. Furthermore, trastuzumab was conjugated to the obtained nanohybrids to enhance the delivery performance to HER2‐expressing tumor cells. Fabricated nanohybrids possessed uniform hydrodynamic diameter and showed typical surface plasmon absorption, which is useful to convert light energy to heat for photothermal therapy. Nanohybrids exhibited T1‐weighted relaxation and comparable MR imaging property to that of commercially available MR contrast reagent. In vitro experiments demonstrated that photothermal effects of nanohybrid under near infrared (NIR) irradiation were sufficient to kill 80%–90% of cancer cells. The combination of the targeted nanohybrid and NIR laser irradiation strongly suppressed tumor growth and extended the survival of HER2‐positive SKOV3 tumor‐bearing nude mice. Therefore, fabricated nanohybrids are promising for targeted photothermal therapy and imaging. | |||||
| 書誌情報 |
Nano Select 巻 2, 号 4, p. 779-790, 発行日 2020-12 |
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| 出版者 | ||||||
| 出版者 | John Wiley & Sons, Inc. | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2688-4011 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1002/nano.202000218 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://onlinelibrary.wiley.com/doi/10.1002/nano.202000218 | |||||
