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Efficacy of vorinostat-sensitized intraperitoneal radioimmunotherapy with 64Cu-labeled cetuximab against peritoneal dissemination of gastric cancer in a mouse model
https://repo.qst.go.jp/records/81880
https://repo.qst.go.jp/records/81880f1170aff-38f3-4e6e-8f96-c2da1c531b08
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-06-23 | |||||
| タイトル | ||||||
| タイトル | Efficacy of vorinostat-sensitized intraperitoneal radioimmunotherapy with 64Cu-labeled cetuximab against peritoneal dissemination of gastric cancer in a mouse model | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Tachibana, Tomoko
× Tachibana, Tomoko× Yoshii, Yukie× Matsumoto, Hiroki× Ming-Rong, Zhang× Nagatsu, Kotaro× Hihara, Fukiko× Igarashi, Chika× Sugyo, Aya× Tsuji, Atsushi× Higashi, Tatsuya× Tomoko, Tachibana× Yukie, Yoshii× Hiroki, Matsumoto× Zhang, Ming-Rong× Kotaro, Nagatsu× Fukiko, Hihara× Chika, Igarashi× Aya, Sugyo× Atsushi, Tsuji× Tatsuya, Higashi |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Gastric cancer is a common cause of cancer-related death worldwide and peritoneal dissemination is the most frequent metastatic pattern of gastric cancer. However, treatment of this disease condition remains difficult. It has been demonstrated that intraperitoneal radioimmunotherapy (ipRIT) with 64Cu-labeled cetuximab (anti-epidermal growth factor receptor antibody; 64Cu-cetuximab) is a potential treatment for peritoneal dissemination of gastrointestinal cancer in vivo. Recent preclinical and clinical studies have also shown that a histone deacetylase inhibitor, vorinostat, effectively sensitized gastrointestinal cancer to external radiation. In the present study, we examined the efficacy of the combined use of vorinostat, as a radiosensitizer during ipRIT with 64Cu-cetuximab in a peritoneal dissemination mouse model with human gastric cancer NUGC4 cells stably expressing red fluorescent protein (NUGC4-RFP cells). The mouse model was treated by ipRIT with 64Cu-cetuximab plus vorinostat, each single treatment, or saline (control). Side effects, including hematological and biochemical parameters, were evaluated in similarly treated, tumor-free mice. Coadministration of ipRIT with 64Cu-cetuximab + vorinostat significantly prolonged survival compared to control and each single treatment. No significant toxicity signals were observed in all treatment groups. Our data suggest that vorinostat is a potentially effective radiosensitizer for use during treatment of peritoneal dissemination of gastric cancer by ipRIT with 64Cu-cetuximab. | |||||
| 書誌情報 |
Journal of Cancer Research and Therapeutics 発行日 2020-11 |
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| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.4103/jcrt.JCRT_124_20 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.cancerjournal.net. | |||||
