WEKO3
アイテム
Individual dose assessment in 99mTc-GSA hepatic scintigraphy using a nine-compartment biokinetic model
https://repo.qst.go.jp/records/81836
https://repo.qst.go.jp/records/818363c786e05-a95e-4cdd-9117-e2413d6e1c35
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-02-16 | |||||
| タイトル | ||||||
| タイトル | Individual dose assessment in 99mTc-GSA hepatic scintigraphy using a nine-compartment biokinetic model | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
khoa Pham, Dang
× khoa Pham, Dang× Kana, Yamazaki× Ryuichi, Nishii× Kotaro, Tani× Osamu, Kurihara× Kazumasa, Inoue× Masahiro, Fukushi× Tatsuya, Higashi× khoa Pham, Dang× Kana, Yamazaki× Ryuichi, Nishii× Kotaro, Tani× Osamu, Kurihara× Tatsuya, Higashi |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Technetium-99m-galactosyl human serum albumin (99mTc-GSA) is a molecular imaging agent used for evaluating hepatic function. 99mTc-GSA hepatic scintigraphy examinations were performed in 50 patients from December 2018 to November 2019 at the QST Hospital in Japan. In order to estimate the individual variation in absorbed doses for each patient, a method of internal dose assessment for multiple organs and tissues in 99mTc-GSA scintigraphy was developed using a nine-compartment biokinetic model that took advantage of the existing models. This method is also expected to give a better understanding of metabolic changes along with the disease progress. Transfer rates related to the liver and blood compartments of the biokinetic model were optimized for each examination by comparing the time-activity curves for the liver and heart derived from the model with those clinically observed on individual dynamic images over the trunk region using the gamma camera after intravenous injection of 99mTc-GSA. Simultaneous differential equations describing the activity in each compartment were numerically analyzed using EQUATRAN-G, a commercial software, by that the total amount of disintegrations taken place in each compartment over a period of 2.5 days, which corresponds to nearly 10 physical half-lives of 99mTc, was obtained. Absorbed doses of several organs and tissues were calculated using the internal dose calculation software, IDAC-Dose 2.1. As a result, the calculated average dose per unit administered activity (mGy/MBq) for the liver was the highest (0.058 ± 0.007 mGy/MBq for females and 0.042 ± 0.009 mGy/MBq for males) compared to other organs and tissues, and the average dose for males was lower than that estimated for healthy males in a past study (0.054 mGy/MBq). | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 15th International Congress of the International Radiation Protection Association (IRPA15) | |||||
| 発表年月日 | ||||||
| 日付 | 2021-01-18 | |||||
| 日付タイプ | Issued | |||||
