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Ultra-small size gelatin nanogel as a blood brain barrier impermeable contrast agent for magnetic resonance imaging
https://repo.qst.go.jp/records/81805
https://repo.qst.go.jp/records/8180582754057-1244-47fa-b681-77ff0cb1b9b9
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-02-10 | |||||
| タイトル | ||||||
| タイトル | Ultra-small size gelatin nanogel as a blood brain barrier impermeable contrast agent for magnetic resonance imaging | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Kimura, Atsushi
× Kimura, Atsushi× Jun-ichiro Jo× Yoshida, Fumiya× Hong, Zhang× Tabata, Yasuhiko× Sumiyoshi, Akira× Taguchi, Mitsumasa× Aoki, Ichio× Atsushi, Kimura× Fumiya, Yoshida× Akira, Sumiyoshi× Mitsumasa, Taguchi× Ichio, Aoki |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Magnetic Resonance Imaging (MRI) contrast agents with rapid renal excretion that do not penetrate the blood brain barrier (BBB) and blood cerebrospinal fluid barrier (BCFB) are preferred for safer and low-risk diagnosis. Gadolinium (Gd)-conjugated nanoparticles have been proposed for use as contrast agents; however, the particle size must range between 1 to 7 nm to ensure rapid renal excretion. In this study, three types of gelatin, dissolved in water at varying concentrations of 0.1–2 wt.%, were irradiated with 5 kGy -rays at 25 °C under aerated conditions to produce ultra-small gelatin nanogels having an average particle size ranging between 6 ± 2 to 21 ± 4 nm. Ultra-small Gd-coordinated gelatin nanogels (GdGN) suitable for use as MRI contrast agents were produced using 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid mono-N-hydroxysuccinimide ester (DOTA-NHS) and DOTA-butylamine as Gd ligand derivatives. Non-cytotoxicity and effective relaxivity of GdGN as a positive MRI contrast agent were verified using in vivo experiments. Rapid renal excretion of GdGN was observed in mice within 1 h with no accumulation in the liver. GdGN did not migrate across the BCFB in normal mice, thus emphasizing its safety as an MRI contrast agent. | |||||
| 書誌情報 |
Acta Biomaterialia 巻 125, p. 290-299, 発行日 2021-02 |
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| 出版者 | ||||||
| 出版者 | Elsevier | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1742-7061 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.actbio.2021.02.016 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3687915 | |||||
