ログイン
言語:

WEKO3

  • トップ
  • ランキング
To
lat lon distance
To

Field does not validate



インデックスリンク

インデックスツリー

メールアドレスを入力してください。

WEKO

One fine body…

WEKO

One fine body…

アイテム

  1. 原著論文

A First-in-human Study of 11C-MTP38, a Novel PET Ligand for Phosphodiesterase 7

https://repo.qst.go.jp/records/81802
https://repo.qst.go.jp/records/81802
8e111af2-56e9-46fb-bc85-85e704efbd87
Item type 学術雑誌論文 / Journal Article(1)
公開日 2021-02-09
タイトル
タイトル A First-in-human Study of 11C-MTP38, a Novel PET Ligand for Phosphodiesterase 7
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 Manabu, Kubota

× Manabu, Kubota

WEKO 1005308

Manabu, Kubota

Search repository
Chie, Seki

× Chie, Seki

WEKO 1005309

Chie, Seki

Search repository
Yasuyuki, Kimura

× Yasuyuki, Kimura

WEKO 1005310

Yasuyuki, Kimura

Search repository
Keisuke, Takahata

× Keisuke, Takahata

WEKO 1005311

Keisuke, Takahata

Search repository
Hitoshi, Shimada

× Hitoshi, Shimada

WEKO 1005312

Hitoshi, Shimada

Search repository
Yuhei, Takado

× Yuhei, Takado

WEKO 1005313

Yuhei, Takado

Search repository
Kiwamu, Matsuoka

× Kiwamu, Matsuoka

WEKO 1005314

Kiwamu, Matsuoka

Search repository
Kenji, Tagai

× Kenji, Tagai

WEKO 1005315

Kenji, Tagai

Search repository
Yasunori, Sano

× Yasunori, Sano

WEKO 1005316

Yasunori, Sano

Search repository
Yamamoto, Yasuharu

× Yamamoto, Yasuharu

WEKO 1005317

Yamamoto, Yasuharu

Search repository
Maki, Okada

× Maki, Okada

WEKO 1005318

Maki, Okada

Search repository
Tatsuya, Kikuchi

× Tatsuya, Kikuchi

WEKO 1005319

Tatsuya, Kikuchi

Search repository
Masanori, Ichise

× Masanori, Ichise

WEKO 1005320

Masanori, Ichise

Search repository
Kazunori, Kawamura

× Kazunori, Kawamura

WEKO 1005321

Kazunori, Kawamura

Search repository
Zhang, Ming-Rong

× Zhang, Ming-Rong

WEKO 1005322

Zhang, Ming-Rong

Search repository
Makoto, Higuchi

× Makoto, Higuchi

WEKO 1005323

Makoto, Higuchi

Search repository
Manabu, Kubota

× Manabu, Kubota

WEKO 1005324

en Manabu, Kubota

Search repository
Chie, Seki

× Chie, Seki

WEKO 1005325

en Chie, Seki

Search repository
Yasuyuki, Kimura

× Yasuyuki, Kimura

WEKO 1005326

en Yasuyuki, Kimura

Search repository
Keisuke, Takahata

× Keisuke, Takahata

WEKO 1005327

en Keisuke, Takahata

Search repository
Hitoshi, Shimada

× Hitoshi, Shimada

WEKO 1005328

en Hitoshi, Shimada

Search repository
Yuhei, Takado

× Yuhei, Takado

WEKO 1005329

en Yuhei, Takado

Search repository
Kiwamu, Matsuoka

× Kiwamu, Matsuoka

WEKO 1005330

en Kiwamu, Matsuoka

Search repository
Kenji, Tagai

× Kenji, Tagai

WEKO 1005331

en Kenji, Tagai

Search repository
Yasunori, Sano

× Yasunori, Sano

WEKO 1005332

en Yasunori, Sano

Search repository
Yamamoto, Yasuharu

× Yamamoto, Yasuharu

WEKO 1005333

en Yamamoto, Yasuharu

Search repository
Maki, Okada

× Maki, Okada

WEKO 1005334

en Maki, Okada

Search repository
Tatsuya, Kikuchi

× Tatsuya, Kikuchi

WEKO 1005335

en Tatsuya, Kikuchi

Search repository
Masanori, Ichise

× Masanori, Ichise

WEKO 1005336

en Masanori, Ichise

Search repository
Kazunori, Kawamura

× Kazunori, Kawamura

WEKO 1005337

en Kazunori, Kawamura

Search repository
Zhang, Ming-Rong

× Zhang, Ming-Rong

WEKO 1005338

en Zhang, Ming-Rong

Search repository
Makoto, Higuchi

× Makoto, Higuchi

WEKO 1005339

en Makoto, Higuchi

Search repository
抄録
内容記述タイプ Abstract
内容記述 Purpose:
Phosphodiesterase 7 (PDE7) is an enzyme that selectively hydrolyses cyclic adenosine monophosphate, and its dysfunction is implicated in neuropsychiatric diseases. However, in vivo visualization of PDE7 in human brains has hitherto not been possible. Using the novel PET ligand 11C-MTP38, which we recently developed, we aimed to image and quantify PDE7 in living human brains.
Methods:
Seven healthy males underwent a 90-min PET scan after injection of 11C-MTP38. We performed arterial blood sampling and metabolite analysis of plasma in six subjects to obtain a metabolite-corrected input function. Regional total distribution volumes (VT’s) were estimated using compartment models, and Logan plot and Ichise multilinear analysis (MA1). We further quantified the specific radioligand binding using the original multilinear reference tissue model (MRTMO) and standardized uptake value ratio (SUVR) method with the cerebellar cortex as reference.
Results:
PET images with 11C-MTP38 showed relatively high retentions in several brain regions, including in the striatum, globus pallidus, and thalamus, as well as fast washout from the cerebellar cortex, in agreement with the known distribution of PDE7. VT values were robustly estimated by two-tissue compartment model analysis (mean VT = 4.2 for the pallidum), Logan plot, and MA1, all in excellent agreement with each other, suggesting the reversibility of 11C-MTP38 binding. Furthermore, there were good agreements between binding values estimated by indirect method and those estimated by both MRTMO and SUVR, indicating that these methods could be useful for reliable quantification of PDE7. Because MRTMO and SUVR do not require arterial blood sampling, they are the most practical for the clinical use of 11C-MTP38-PET. Conclusion:
We have provided the first demonstration of PET visualization of PDE7 in human
書誌情報 European Journal of Nuclear Medicine and Molecular Imaging

巻 48, 号 9, p. 2846-2855, 発行日 2021-02
ISSN
収録物識別子タイプ ISSN
収録物識別子 1619-7070
PubMed番号
識別子タイプ PMID
関連識別子 33566152
DOI
識別子タイプ DOI
関連識別子 10.1007/s00259-021-05235-0
関連サイト
識別子タイプ URI
関連識別子 https://link.springer.com/article/10.1007/s00259-021-05235-0
戻る
0
views
See details
Views

Versions

Ver.1 2023-05-15 17:26:57.274717
Show All versions

Share

Mendeley Twitter Facebook Print Addthis

Cite as

エクスポート

OAI-PMH
  • OAI-PMH JPCOAR 2.0
  • OAI-PMH JPCOAR 1.0
  • OAI-PMH DublinCore
  • OAI-PMH DDI
Other Formats
  • JSON
  • BIBTEX

Confirm


Powered by WEKO3


Powered by WEKO3