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Metabolic studies of astatine- and radioiodine-labeled neopentyl derivatives
https://repo.qst.go.jp/records/81750
https://repo.qst.go.jp/records/81750c125a676-bd0b-4751-b2f9-9a10cda52825
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-02-01 | |||||
| タイトル | ||||||
| タイトル | Metabolic studies of astatine- and radioiodine-labeled neopentyl derivatives | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Yuta, Kaizuka (Chiba Univ.)
× Yuta, Kaizuka (Chiba Univ.)× Hiroyuki, Suzuki (Chiba Univ.)× Hiroshi, Tanaka (Tokyo Inst. of Technology)× Nana, Washiya (Chiba Univ)× Yui, Saito (Chiba Univ)× Maho, Tatsuta (Tokyo Inst. of Technology)× Shigeki, Watanabe× Noriko, Ishioka× Yoshifumi, Shirakami (Osaka Univ.)× Kazuhiro, Ooe (Osaka Univ.)× Atsushi, Toyoshima (Osaka Univ.)× Jun, Hatazawa (Osaka Univ.)× Yasushi, Arano (Chiba Univ.)× Tomoya, Uehara (Chiba Univ.)× Shigeki, Watanabe× Noriko, Ishioka |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Astatine-211 (211At) is one of the most promising radionuclides for targeted α therapy of cancers and radioiodine such as iodine-123 is useful radionuclide for diagnosis. Because astatine and iodine are the same group, halogen, the same scaffolds could be used for astatination and radioiodination to prepare radiotheranostics compounds. However, the in vivo instability of 211At-labeling agents such as 211At-benzoate limits the application of 211At to various compounds. To overcome the problem and expand the application of 211At-labeled compounds to radiotheranostics, we developed neopentyl derivatives as a novel scaffold for astatination and radioiodination. The stability and biodistribution of 211At or 125I-labeled neopentyl derivatives were compared with reference compounds radiolabeled with 125I or 211At via a conventional method using benzamide. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | SNMMI2020 Annual Meeting | |||||
| 発表年月日 | ||||||
| 日付 | 2020-06-11 | |||||
| 日付タイプ | Issued | |||||
