WEKO3
アイテム
Estimating the biological effects of helium, carbon, oxygen, and neon ion beams using 3D silicon microdosimeters
https://repo.qst.go.jp/records/81606
https://repo.qst.go.jp/records/8160610e02480-89c4-48df-a1aa-0cde362fcd2a
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-01-08 | |||||
| タイトル | ||||||
| タイトル | Estimating the biological effects of helium, carbon, oxygen, and neon ion beams using 3D silicon microdosimeters | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Hyun Lee, Sung
× Hyun Lee, Sung× Mizushima, Kota× Kohno, Ryosuke× Iwata, Yoshiyuki× Yonai, Shunsuke× Shirai, Toshiyuki× A Pan, Vladimir× Bolst, David× T Tran, Linh× B Rosenfeld, Anatoly× Suzuki, Masao× Inaniwa, Taku× Sung-Hyun, Lee× Kota, Mizushima× Ryosuke, Kohno× Yoshiyuki, Iwata× Shunsuke, Yonai× Toshiyuki, Shirai× Masao, Suzuki× Taku, Inaniwa |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | In this study, the survival fraction (SF) and relative biological effectiveness (RBE) of pancreatic cancer cells exposed to spread-out Bragg peak (SOBP) helium, carbon, oxygen, and neon ion beams are estimated from the measured microdosimetric spectra using a microdosimeter and the application of the microdosimetric kinetic (MK) model. To measure the microdosimetric spectra, a 3D mushroom silicon-on-insulator (SOI) microdosimeter connected to low noise readout electronics (MicroPlus probe) was used. The parameters of the MK model were determined for pancreatic cancer cells such that the calculated SFs reproduced previously reported in vitro SF data. For a cuboid target of 10×10×6 cm, treatment plans of helium, carbon, oxygen, and neon ion beams were designed using in-house treatment planning software (TPS) to achieve a 10% SF of pancreatic cancer cells throughout the target. The physical doses and microdosimetric spectra of the planned fields were measured at different depths in polymethyl methacrylate (PMMA) phantoms. The biological effects, such as SF, RBE, and RBE-weighted dose at different depths along the fields were predicted from the measurements. The predicted SFs at the target region were generally in good agreement with the planned SF from the TPS in most cases. | |||||
| 書誌情報 |
Physics in medicine and biology 巻 66, 号 4, p. 045017, 発行日 2020-12 |
|||||
| 出版者 | ||||||
| 出版者 | IOP Publishing | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0031-9155 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 33361575 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1088/1361-6560/abd66f | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://iopscience.iop.org/article/10.1088/1361-6560/abd66f | |||||
