WEKO3
アイテム
Fluorescent Nanodiamonds Embedded in Poly-ε-Caprolactone Fibers as Biomedical Scaffolds
https://repo.qst.go.jp/records/81565
https://repo.qst.go.jp/records/815656b97f853-4683-4090-b667-a698cc1a5687
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-01-06 | |||||
| タイトル | ||||||
| タイトル | Fluorescent Nanodiamonds Embedded in Poly-ε-Caprolactone Fibers as Biomedical Scaffolds | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Guarino, Vincenzo
× Guarino, Vincenzo× Iriczalli, Cruz-Maya× Reineck, Philipp× Abe, Hiroshi× Ohshima, Takeshi× Fox, Kate× D. Greentree, Andrew× C. Gibson, Brant× Ambrosio, Luigi× Hiroshi, Abe× Takeshi, Ohshima |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Fluorescent nanodiamonds (fNDs) are emerging as important tools for imaging and sensing in biology, which enable the optical detection, for example, of temperature and magnetic fields at the nanoscale. At the same time, their unique physicochemical properties allow fNDs to drastically improve the properties of nanocomposites. Here, we report the integration of fNDs into electrospun poly-ε-caprolactone (PCL) fibers and the use of the resulting hybrid material as a nontoxic and multifunctional bioscaffold. We investigate the morphology, size distribution, optical properties, wettability, and biocompatibility of PCL fibers containing 0.2 and 0.4 wt % fNDs and demonstrate the quantum sensing capability of the nanocomposite via optically detected magnetic resonance measurements of the nitrogen-vacancy center in fNDs. We find that the use of ethanol as a cosolvent improves the dispersion of fNDs into PCL fibers and reduces the occurrence of fiber defects. We demonstrate that the PCL/fND scaffold is not cytotoxic for mesenchymal stem cells and even promotes cell adhesion and cell proliferation up to 21 days because of an increase in wettability compared to pure PCL fibers. Our results highlight the immense potential of PCL/fND nanocomposites as smart bioscaffolds for advanced biomedical applications such as tissue engineering, biosensing, and theranostics. |
|||||
| 書誌情報 |
ACS Applied Nano Materials 巻 3, 号 11, p. 10814-10822, 発行日 2021-01 |
|||||
| 出版者 | ||||||
| 出版者 | American Chemical Society | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2574-0970 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1021/acsanm.0c02103 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://pubs.acs.org/doi/10.1021/acsanm.0c02103# | |||||
