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Dose quantification in carbon ion therapy using in-beam positron emission tomography
https://repo.qst.go.jp/records/81514
https://repo.qst.go.jp/records/815147f088e07-0144-47cf-9435-d09069356fb0
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-12-24 | |||||
| タイトル | ||||||
| タイトル | Dose quantification in carbon ion therapy using in-beam positron emission tomography | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Rutherford, Harley
× Rutherford, Harley× Chacon, Andrew× Mohammadi, Akram× Takyu, Sodai× Tashima, Hideaki× Yoshida, Eiji× Nishikido, Fumihiko× Hofmann, Teresa× Pinto, Marco× R Franklin, Daniel× Yamaya, Taiga× Parodi, Katia× B Rosenfeld, Anatoly× Guatelli, Susanna× Safavi naeini, Mitra× Rutherford, Harley× Chacon, Andrew× Mohammadi, Akram× Sodai, Takyu× Hideaki, Tashima× Eiji, Yoshida× Fumihiko, Nishikido× Taiga, Yamaya× Parodi, Katia× Safavi naeini, Mitra |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | This work presents an iterative method for the estimation of the absolute dose distribution in patients undergoing carbon ion therapy, via analysis of the distribution of positron annihilations resulting from the decay of positron-emitting fragments created in the target volume. The proposed method relies on the decomposition of the total positron-annihilation distributions into profiles of the three principal positron-emitting fragment species - 11C, 10C and 15O. A library of basis functions is constructed by simulating a range of monoenergetic 12C ion irradiations of a homogeneous polymethyl methacrylate phantom and measuring the resulting one-dimensional positron-emitting fragment profiles and dose distributions. To estimate the dose delivered during an arbitrary polyenergetic irradiation, a linear combination of factors from the fragment profile library is iteratively fitted to the decomposed positron annihilation profile acquired during the irradiation, and the resulting weights combined with the corresponding monoenergetic dose profiles to estimate the total dose distribution. A total variation regularisation term is incorporated into the fitting process to suppress high-frequency noise. The method was evaluated with 14 different polyenergetic 12C dose profiles in a polymethyl methacrylate target: one which produces a flat biological dose, 10 with randomised energy weighting factors, and three with distinct dose maxima or minima within the spread-out Bragg peak region. The proposed method is able to calculate the dose profile with mean relative errors of 0.8%, 1.0% and 1.6% from the 11C, 10C, 15O fragment profiles, respectively, and estimate the position of the distal edge of the SOBP to within an average of 0.7 mm, 1.9 mm and 1.2 mm of its true location. |
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| 書誌情報 |
Physics in Medicine & Biology 巻 65, 号 23, p. 235052, 発行日 2020-12 |
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| 出版者 | ||||||
| 出版者 | IOP Publishing | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0031-9155 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1088/1361-6560/abaa23 | |||||
| 関連サイト | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1088/1361-6560/abaa23 | |||||
