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Advances in modelling gold nanoparticle radiosensitization using new Geant4-DNA physics models
https://repo.qst.go.jp/records/81251
https://repo.qst.go.jp/records/81251c8e4bb18-3f5e-46ca-ac37-d14dc862c42a
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-12-09 | |||||
| タイトル | ||||||
| タイトル | Advances in modelling gold nanoparticle radiosensitization using new Geant4-DNA physics models | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Engels, Elette
× Engels, Elette× Bakr, Samer× Bolst, David× Dousatsu Sakata× Li, Nan× Lazarakis, Peter× J McMahon, Stephen× Ivanchenko, Vladimir× B Rosenfeld, Anatoly× Incerti, Sebastien× Kyriakou, Ioanna× Emfietzoglou, Dimitris× L F Lerch, Michael× Tehei, Moeava× Corde, Stephanie× Guatelli, Susanna× Dousatsu, Sakata |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Gold nanoparticles have demonstrated significant radiosensitization of cancer treatment with x-ray radiotherapy. To understand the mechanisms at the basis of nanoparticle radiosensitization, Monte Carlo simulations are used to investigate the dose enhancement, given a certain nanoparticle concentration and distribution in the biological medium. Earlier studies have ordinarily used condensed history physics models to predict nanoscale dose enhancement with nanoparticles. This study uses Geant4-DNA complemented with novel track structure physics models to accurately describe electron interactions in gold and to calculate the dose surrounding gold nanoparticle structures at nanoscale level. The computed dose in silico due to a clinical kilovoltage beam and the presence of gold nanoparticles was related to in vitro brain cancer cell survival using the local effect model. The comparison of the simulation results with radiobiological experimental measurements shows that Geant4-DNA and local effect model can be used to predict cell survival in silico in the case of x-ray kilovoltage beams. | |||||
| 書誌情報 |
Physics in Medicine & Biology 巻 65, 号 22, p. 225017, 発行日 2020-11 |
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| 出版者 | ||||||
| 出版者 | IOP Publishing | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0031-9155 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1088/1361-6560/abb7c2 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://iopscience.iop.org/article/10.1088/1361-6560/abb7c2 | |||||
