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Protective Effects of p53 Regulatory Agents Against High-LET Radiation-Induced Injury in Mice
https://repo.qst.go.jp/records/81241
https://repo.qst.go.jp/records/81241554df4f9-bbdb-4c5d-9b23-ff1f6f31c1b9
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-12-07 | |||||
| タイトル | ||||||
| タイトル | Protective Effects of p53 Regulatory Agents Against High-LET Radiation-Induced Injury in Mice | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Akinori, Morita
× Akinori, Morita× Wang, Bing× Tanaka, Kaoru× Katsube, Takanori× Murakami, Masahiro× Shimokawa, Takashi× Nishiyama, Yuichi× Ochi, Shintaro× Satoh, Hidetoshi× Nenoi, Mitsuru× Aoki, Shinya× Akinori, Morita× Bing, Wang× Kaoru, Tanaka× Takanori, Katsube× Masahiro, Murakami× Takashi, Shimokawa× Yuichi, Nishiyama× Shintaro, Ochi× Mitsuru, Nenoi× Shinya, Aoki |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Radiation damage to normal tissues is one of the most serious concerns in radiation therapy, and the tolerance dose of the normal tissues limits the therapeutic dose to the patients. p53 is well known as a transcription factor closely associated with radiation-induced cell death. We recently demonstrated the protective effects of several p53 regulatory agents against low‐LET X‐ or γ-ray-induced damage. Although it was reported that high‐LET heavy ion radiation (> 85 keV/μm) could cause p53‐independent cell death in some cancer cell lines, whether there is any radioprotective effect of the p53 regulatory agents against the high-LET radiation injury in vivo is still unclear. In the present study, we verified the efficacy of these agents on bone marrow and intestinal damages induced by high-LET heavy-ion irradiation in mice. We used a carbon-beam (14 keV/μm) that was shown to induce a p53-dependent effect and an iron-beam (189 keV/μm) that was shown to induce a p53-independent effect in a previous study. Vanadate significantly improved 60-day survival rate in mice treated with total-body carbon-ion (p < 0.0001) or iron-ion (p < 0.05) irradiation, indicating its effective protection of the hematopoietic system from radiation injury after high-LET irradiation over 85 keV/μm. 5CHQ also significantly increased the survival rate after abdominal carbon‐ion (p < 0.02), but not iron‐ion irradiation, suggesting the moderate relief of the intestinal damage. These results demonstrated the effectiveness of p53 regulators on acute radiation syndrome induced by high-LET radiation. キーワード：p53, Radioprotector, Cell Death, Hematopoietic syndrome, Gastrointestinal syndrome |
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| 書誌情報 |
Frontiers in Public Health 巻 8, p. 601124, 発行日 2020-12 |
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| 出版者 | ||||||
| 出版者 | Frontiers Media S.A. | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2296-2565 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.3389/fpubh.2020.601124 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.frontiersin.org/articles/10.3389/fpubh.2020.601124/full | |||||
