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Differential associations of dopamine synthesis capacity with the dopamine transporter and D2 receptor availability as assessed by PET in the living human brain
https://repo.qst.go.jp/records/81102
https://repo.qst.go.jp/records/811026c022b39-a19b-4692-8bb8-e394dfa7e592
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-11-25 | |||||
| タイトル | ||||||
| タイトル | Differential associations of dopamine synthesis capacity with the dopamine transporter and D2 receptor availability as assessed by PET in the living human brain | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Yamamoto, Yasuharu
× Yamamoto, Yasuharu× Takahata, Keisuke× Kubota, Manabu× Takano, Harumasa× Takeuchi, Hiroyoshi× Kimura, Yasuyuki× Sano, Yasunori× Kurose, Shin× Hiroshi Ito× Mimura, Masaru× Higuchi, Makoto× Yamamoto, Yasuharu× Keisuke, Takahata× Manabu, Kubota× Harumasa, Takano× Yasuyuki, Kimura× Yasunori, Sano× Shin, Kurose× Makoto, Higuchi |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background: The dopamine (DA) neurotransmission has been implicated in fundamental brain functions, exem- plified by movement controls, reward-seeking, motivation, and cognition. Although dysregulation of DA neuro- transmission in the striatum is known to be involved in diverse neuropsychiatric disorders, it is yet to be clarified whether components of the DA transmission, such as synthesis, receptors, and reuptake are coupled with each other to homeostatically maintain the DA neurotransmission. The purpose of this study was to investigate asso- ciations of the DA synthesis capacity with the availabilities of DA transporters and D2 receptors in the striatum of healthy subjects. Methods: First, we examined correlations between the DA synthesis capacity and DA transporter availability in the caudate and putamen using PET data with L-[ ????- 11 C]DOPA and [ 18 F]FE-PE2I, respectively, acquired from our past dual-tracer studies. Next, we investigated relationships between the DA synthesis capacity and D2 recep- tor availability employing PET data with L-[ ????- 11 C]DOPA and [ 11 C]raclopride, respectively, obtained from other previous dual-tracer assays. Results: We found a significant positive correlation between the DA synthesis capacity and DA transporter avail- ability in the putamen, while no significant correlations between the DA synthesis capacity and D2 receptor availability in the striatum. Conclusion: The intimate association of the DA synthesis rate with the presynaptic reuptake of DA indicates home- ostatic maintenance of the baseline synaptic DA concentration. In contrast, the total abundance of D2 receptors, which consist of presynaptic autoreceptors and postsynaptic modulatory receptors, may not have an immediate relationship to this regulatory mechanism. | |||||
| 書誌情報 |
NeuroImage 巻 226, p. 117543, 発行日 2020-11 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1053-8119 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 33186713 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.neuroimage.2020.117543 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.sciencedirect.com/science/article/pii/S1053811920310284?dgcid=rss_sd_all | |||||
