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Emerging BRAF mutations in cancer progression and their possible effects on transcriptional networks
https://repo.qst.go.jp/records/80957
https://repo.qst.go.jp/records/809573e202007-5865-4a09-a445-836630351269
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-10-06 | |||||
| タイトル | ||||||
| タイトル | Emerging BRAF mutations in cancer progression and their possible effects on transcriptional networks | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Magdalena, Śmiech
× Magdalena, Śmiech× Paweł, Leszczyński× Kono, Hidetoshi× DoDo, Kosuke× Wardell, Christopher× Taniguchi, Hiroaki× Hidetoshi, Kono |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Gene mutations can induce cellular alteration and malignant transformation. Development of many types of cancer is associated with mutations in the BRAF (B-raf proto-oncogene) gene. The encoded protein is a component of the MAPK/ERK (mitogen-activated protein kinases/extracellular signal-regulated kinases) signaling pathway, transmitting information from the outside to the cell nucleus. The main function of the MAPK/ERK pathway is to regulate cell growth, migration, and proliferation. The most common mutations in the BRAF gene encode the V600E mutant (class I), which causes continuous activation and signal transduction, regardless of external stimulus. Consequently, cell proliferation and invasion are enhanced in cancer patients with such mutations. The V600E mutation has been linked to melanoma, colorectal cancer, multiple myeloma, and other types of cancers. Importantly, emerging evidence has recently indicated that a new type of mutations (class II and III) also play a paramount role in the development of cancer. In this minireview, we discuss the influence of various BRAF mutations in cancer, including aberrant transcriptional gene regulation in the affected tissues. | |||||
| 書誌情報 |
Genes 巻 11, 号 11, p. 1342, 発行日 2020-11 |
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| 出版者 | ||||||
| 出版者 | MDPI | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2073-4425 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.3390/genes11111342 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.mdpi.com/2073-4425/11/11/1342 | |||||
