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First Prototyping of a Total-Body Small Animal PET with a 4-Layer DOI Detector
https://repo.qst.go.jp/records/80859
https://repo.qst.go.jp/records/808591828af40-b365-429a-a764-91bf963a8516
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-11-02 | |||||
| タイトル | ||||||
| タイトル | First Prototyping of a Total-Body Small Animal PET with a 4-Layer DOI Detector | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Kang, Hangyu
× Kang, Hangyu× Kang, Hangyu |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Recently, a total-body positron emission tomography (PET) scanner, which was developed by UC Davis, enabled the total-body dynamic molecular imaging with a subsecond temporal resolution in a human study. However, when it comes to small animal PET, the long axial field-of-view (FOV) causes a parallax error not only in the radial direction but also in the axial direction. In a previous simulation study, we demonstrated that a total-body small animal PET scanner with a 4-layer depth-of-interaction (DOI) detector can reduce the parallax error substantially. In this study, we present the first imaging results with the prototype total-body small animal PET (TBSAP) scanner. The proposed TBSAP scanner has an inner diameter of 155 mm and an axial length of 325.6 mm which can cover a rat whole-body. The TBSAP consists of 6 rings each of which has 10 DOI detectors Five of 6 rings are used since the detector calibration of the 6th ring has not been finished yet. Each DOI PET detector consists of a 4-layer Zr-doped gadolinium oxyorthosilicate (GSOZ) crystal array and an 8×8 array multi-anode PMT. Each crystal layer has a 16×16 array of GSOZ crystals (2.8×2.8×7.5 mm3) which yields a total crystal thickness of 30 mm. The PMT anode signals are multiplexed using a resistive network, and then digitized by the 8-bit DAQ system (Hamamatsu, Japan). The 2.2 mm rod of the Derenzo-like phantom can be resolved even with the 30 mm radial offset. The peak sensitivity of 16.7% is obtained at the center of the FOV. The parallax error along the radial and axial directions can be reduced by using the 4-layer DOI detector. In the near future, we will perform a real-time dynamic animal imaging study with the prototype PET scanner. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 2020 Virtual IEEE Nuclear Science Symposium and Medical Imaging Conference | |||||
| 発表年月日 | ||||||
| 日付 | 2020-11-06 | |||||
| 日付タイプ | Issued | |||||
