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  1. 原著論文

Heavy Tau Burden with Subtle Amyloid β Accumulation in the Cerebral Cortex and Cerebellum in a Case of Familial Alzheimer’s Disease with APP Osaka Mutation

https://repo.qst.go.jp/records/80854
https://repo.qst.go.jp/records/80854
ba70b689-de36-4fdb-b8a7-0f8025e83aa5
Item type 学術雑誌論文 / Journal Article(1)
公開日 2020-11-02
タイトル
タイトル Heavy Tau Burden with Subtle Amyloid β Accumulation in the Cerebral Cortex and Cerebellum in a Case of Familial Alzheimer’s Disease with APP Osaka Mutation
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 Shimada, Hiroyuki

× Shimada, Hiroyuki

WEKO 1002788

Shimada, Hiroyuki

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Minatani, Shinobu

× Minatani, Shinobu

WEKO 1002789

Minatani, Shinobu

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Takeuchi, Jun

× Takeuchi, Jun

WEKO 1002790

Takeuchi, Jun

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Takeda, Akitoshi

× Takeda, Akitoshi

WEKO 1002791

Takeda, Akitoshi

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Joji Kawabe

× Joji Kawabe

WEKO 1002792

Joji Kawabe

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Wada, Yasuhiro

× Wada, Yasuhiro

WEKO 1002793

Wada, Yasuhiro

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Mawatari, Aya

× Mawatari, Aya

WEKO 1002794

Mawatari, Aya

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Yasuyoshi Watanabe

× Yasuyoshi Watanabe

WEKO 1002795

Yasuyoshi Watanabe

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Shimada, Hitoshi

× Shimada, Hitoshi

WEKO 1002796

Shimada, Hitoshi

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Higuchi, Makoto

× Higuchi, Makoto

WEKO 1002797

Higuchi, Makoto

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Suhara, Tetsuya

× Suhara, Tetsuya

WEKO 1002798

Suhara, Tetsuya

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Tomiyama, Takami

× Tomiyama, Takami

WEKO 1002799

Tomiyama, Takami

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Itoh, Yoshiaki

× Itoh, Yoshiaki

WEKO 1002800

Itoh, Yoshiaki

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Hitoshi, Shimada

× Hitoshi, Shimada

WEKO 1002801

en Hitoshi, Shimada

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Makoto, Higuchi

× Makoto, Higuchi

WEKO 1002802

en Makoto, Higuchi

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Tetsuya, Suhara

× Tetsuya, Suhara

WEKO 1002803

en Tetsuya, Suhara

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抄録
内容記述タイプ Abstract
内容記述 We previously identified a novel mutation in amyloid precursor protein from a Japanese pedigree of familial Alzheimer's disease, FAD (Osaka). Our previous positron emission tomography (PET) study revealed that amyloid β (Aβ) accumulation was negligible in two sister cases of this pedigree, indicating a possibility that this mutation induces dementia without forming senile plaques. To further explore the relationship between Aβ, tau and neurodegeneration, we performed tau and Aβ PET imaging in the proband of FAD (Osaka) and in patients with sporadic Alzheimer's disease (SAD) and healthy controls (HCs). The FAD (Osaka) patient showed higher uptake of tau PET tracer in the frontal, lateral temporal, and parietal cortices, posterior cingulate gyrus and precuneus than the HCs (>2.5 SD) and in the lateral temporal and parietal cortices than the SAD patients (>2 SD). Most noticeably, heavy tau tracer accumulation in the cerebellum was found only in the FAD (Osaka) patient. Scatter plot analysis of the two tracers revealed that FAD (Osaka) exhibits a distinguishing pattern with a heavy tau burden and subtle Aβ accumulation in the cerebral cortex and cerebellum. These observations support our hypothesis that Aβ can induce tau accumulation and neuronal degeneration without forming senile plaques.
書誌情報 International Journal of Molecular Sciences

巻 21, 号 12, p. 4443, 発行日 2020-06
出版者
出版者 MDPI
ISSN
収録物識別子タイプ ISSN
収録物識別子 1422-0067
PubMed番号
識別子タイプ PMID
関連識別子 32580499
DOI
識別子タイプ DOI
関連識別子 10.3390/ijms21124443
関連サイト
識別子タイプ URI
関連識別子 https://www.mdpi.com/1422-0067/21/12/4443
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