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  1. 原著論文

High-Contrast In Vivo Imaging of Tau Pathologies in Alzheimer’s and Non-Alzheimer’s Disease Tauopathies

https://repo.qst.go.jp/records/80851
https://repo.qst.go.jp/records/80851
c33d6428-d89c-44ee-b8ea-63dccd2df55f
Item type 学術雑誌論文 / Journal Article(1)
公開日 2020-10-30
タイトル
タイトル High-Contrast In Vivo Imaging of Tau Pathologies in Alzheimer’s and Non-Alzheimer’s Disease Tauopathies
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 Tagai, Kenji

× Tagai, Kenji

WEKO 1007835

Tagai, Kenji

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Ono, Maiko

× Ono, Maiko

WEKO 1007836

Ono, Maiko

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Kubota, Manabu

× Kubota, Manabu

WEKO 1007837

Kubota, Manabu

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Kitamura, Soichiro

× Kitamura, Soichiro

WEKO 1007838

Kitamura, Soichiro

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Takahata, Keisuke

× Takahata, Keisuke

WEKO 1007839

Takahata, Keisuke

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Seki, Chie

× Seki, Chie

WEKO 1007840

Seki, Chie

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Takado, Yuhei

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WEKO 1007841

Takado, Yuhei

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Shinoto, Hitoshi

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Shinoto, Hitoshi

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Sano, Yasunori

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WEKO 1007843

Sano, Yasunori

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Yamamoto, Yasuharu

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Yamamoto, Yasuharu

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Matsuoka, Kiwamu

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Matsuoka, Kiwamu

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Takuwa, Hiroyuki

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WEKO 1007846

Takuwa, Hiroyuki

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Shimojo, Masafumi

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WEKO 1007847

Shimojo, Masafumi

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Takahashi , Manami

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WEKO 1007848

Takahashi , Manami

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Kawamura, Kazunori

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WEKO 1007849

Kawamura, Kazunori

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Kikuchi, Tatsuya

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WEKO 1007850

Kikuchi, Tatsuya

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Okada, Maki

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WEKO 1007851

Okada, Maki

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Akiyama, Haruhiko

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WEKO 1007852

Akiyama, Haruhiko

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Suzuki, Hisaomi

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WEKO 1007853

Suzuki, Hisaomi

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Onaya, Mitsumoto

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Onaya, Mitsumoto

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Takeda, Takahiro

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Arai, Kimihito

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Arai, Nobutaka

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Araki, Nobuyuki

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Saito, Yuko

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Q. Trojanowski, John

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Q. Trojanowski, John

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M.Y. Lee, Virginia

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M.Y. Lee, Virginia

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K. Mishra, Sushil

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K. Mishra, Sushil

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Yamaguchi, Yoshiki

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Yamaguchi, Yoshiki

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Kimura, Yasuyuki

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Kimura, Yasuyuki

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Ichise, Masanori

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Ichise, Masanori

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Tomita, Yutaka

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WEKO 1007866

Tomita, Yutaka

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Ming-Rong, Zhang

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Suhara, Tetsuya

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Shigeta, Masahiro

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Sahara, Naruhiko

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Higuchi, Makoto

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Shimada, Hitoshi

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Kenji, Tagai

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Maiko, Ono

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Manabu, Kubota

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Soichiro, Kitamura

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Keisuke, Takahata

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Chie, Seki

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Yuhei, Takado

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Hitoshi, Shinoto

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Yasunori, Sano

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Yamamoto, Yasuharu

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Kiwamu, Matsuoka

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Hiroyuki, Takuwa

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Masafumi, Shimojo

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Takahashi, Manami

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Kazunori, Kawamura

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Tatsuya, Kikuchi

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Maki, Okada

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Hisaomi, Suzuki

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Yasuyuki, Kimura

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Masanori, Ichise

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Yutaka, Tomita

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Zhang, Ming-Rong

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Tetsuya, Suhara

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Naruhiko, Sahara

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Makoto, Higuchi

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Hitoshi, Shimada

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抄録
内容記述タイプ Abstract
内容記述 A panel of radiochemicals has enabled in vivo positron emission tomography (PET) of tau pathologies in Alzheimer’s disease (AD), although sensitive detection of frontotemporal lobar degeneration (FTLD) tau inclusions has been unsuccessful. Here, we generated an imaging probe, PM-PBB3, for capturing diverse tau deposits. In vitro assays demonstrated the reactivity of this compound with tau pathologies in AD and FTLD. We could also utilize PM-PBB3 for optical/PET imaging of a living murine tauopathy model. A subsequent clinical PET study revealed increased binding of 18F-PM-PBB3 in diseased patients, reflecting cortical-dominant AD and subcortical-dominant progressive supranuclear palsy (PSP) tau topologies. Notably, the in vivo reactivity of 18F-PM-PBB3 with FTLD tau inclusion was strongly supported by neuropathological examinations of brains derived from Pick’s disease, PSP, and corticobasal degeneration patients who underwent PET scans. Finally, visual inspection of 18F-PM-PBB3-PET images was indicated to facilitate individually based identification of diverse clinical phenotypes of FTLD on a neuropathological basis.
書誌情報 Neuron

巻 109, 号 1, p. 42-58.e8, 発行日 2020-10
出版者
出版者 Elsevier
ISSN
収録物識別子タイプ ISSN
収録物識別子 0896-6273
PubMed番号
識別子タイプ PMID
関連識別子 33125873
DOI
識別子タイプ DOI
関連識別子 10.1016/j.neuron.2020.09.042
関連サイト
識別子タイプ URI
関連識別子 https://www.sciencedirect.com/science/article/pii/S0896627320307662
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