{"_buckets": {"deposit": "1dfc1b28-9bf6-4d09-bf54-a3fa0514fed4"}, "_deposit": {"created_by": 1, "id": "80793", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "80793"}, "status": "published"}, "_oai": {"id": "oai:repo.qst.go.jp:00080793", "sets": ["1"]}, "author_link": ["1027186", "1027192", "1027206", "1027184", "1027199", "1027188", "1027197", "1027200", "1027205", "1027189", "1027182", "1027179", "1027204", "1027209", "1027183", "1027201", "1027210", "1027202", "1027191", "1027208", "1027198", "1027203", "1027180", "1027193", "1027187", "1027195", "1027196", "1027207", "1027190", "1027185", "1027178", "1027194", "1027181"], "item_8_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2020-09", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "63", "bibliographicPageEnd": "11483", "bibliographicPageStart": "11469", "bibliographicVolumeNumber": "2020", "bibliographic_titles": [{"bibliographic_title": "Journal of Medicinal Chemistry"}]}]}, "item_8_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Metabotropic glutamate receptor 2 (mGlu2) is a known target for treating several central nervous system (CNS) disorders. To develop a viable positron emission tomography (PET) ligand for mGlu2, we identified new candidates 5a–i that are potent negative allosteric modulators (NAMs) of mGlu2. Among these candidates, 4-(2-fluoro-4-methoxyphenyl)-5-((1-methyl-1H-pyrazol-3-yl)methoxy)picolinamide (5i, also named as [11C]MG2-1812) exhibited high potency, high subtype selectivity, and favorable lipophilicity. Compound 5i was labeled with positron-emitting carbon-11 (11C) to obtain [11C]5i in high radiochemical yield and high molar activity by O-[11C]methylation of the phenol precursor 12 with [11C]CH3I. In vitro autoradiography with [11C]5i showed heterogeneous radioactive accumulation in the brain tissue sections, ranked in the order: cortex \u003e striatum \u003e hippocampus \u003e cerebellum ≫ thalamus \u003e pons. PET study of [11C]5i indicated in vivo specific binding of mGlu2 in the rat brain. Based on the [11C]5i scaffold, further optimization for new candidates is underway to identify a more suitable ligand for imaging mGlu2.", "subitem_description_type": "Abstract"}]}, "item_8_publisher_8": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "ACS Publications"}]}, "item_8_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1021/acs.jmedchem.9b01991", "subitem_relation_type_select": "DOI"}}]}, "item_8_relation_17": {"attribute_name": "関連サイト", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "https://pubs.acs.org/doi/10.1021/acs.jmedchem.9b01991", "subitem_relation_type_select": "URI"}}]}, "item_8_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0022-2623", "subitem_source_identifier_type": "ISSN"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "metadata only access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_14cb"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Yamasaki, Tomoteru"}], "nameIdentifiers": [{"nameIdentifier": "1027178", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Zhang, Xiaofei"}], "nameIdentifiers": [{"nameIdentifier": "1027179", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kumata, Katsushi"}], "nameIdentifiers": [{"nameIdentifier": "1027180", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Zhang, Yiding"}], "nameIdentifiers": [{"nameIdentifier": "1027181", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Deng, Xiaoyun"}], "nameIdentifiers": [{"nameIdentifier": "1027182", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Fujinaga, Masayuki"}], "nameIdentifiers": [{"nameIdentifier": "1027183", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Chen, Zhen"}], "nameIdentifiers": [{"nameIdentifier": "1027184", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Mori, Wakana"}], "nameIdentifiers": [{"nameIdentifier": "1027185", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kuan, Hu"}], "nameIdentifiers": [{"nameIdentifier": "1027186", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Wakizaka, Hidekatsu"}], "nameIdentifiers": [{"nameIdentifier": "1027187", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hatori, Akiko"}], "nameIdentifiers": [{"nameIdentifier": "1027188", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Xie, Lin"}], "nameIdentifiers": [{"nameIdentifier": "1027189", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ogawa, Masanao"}], "nameIdentifiers": [{"nameIdentifier": "1027190", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nengaki, Nobuki"}], "nameIdentifiers": [{"nameIdentifier": "1027191", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Van, Richard"}], "nameIdentifiers": [{"nameIdentifier": "1027192", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shao, Yihan"}], "nameIdentifiers": [{"nameIdentifier": "1027193", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "J. Sheffler, Douglas"}], "nameIdentifiers": [{"nameIdentifier": "1027194", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "D. P. Cosford, Nicholas"}], "nameIdentifiers": [{"nameIdentifier": "1027195", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Liang, Huan"}], "nameIdentifiers": [{"nameIdentifier": "1027196", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ming-Rong, Zhang"}], "nameIdentifiers": [{"nameIdentifier": "1027197", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tomoteru, Yamasaki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1027198", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Katsushi, Kumata", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1027199", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Zhang, Yiding", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1027200", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Masayuki, Fujinaga", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1027201", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Wakana, Mori", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1027202", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kuan, Hu", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1027203", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hidekatsu, Wakizaka", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1027204", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Akiko, Hatori", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1027205", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Lin, Xie", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1027206", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Masanao, Ogawa", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1027207", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nobuki, Nengaki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1027208", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Liang, Huan", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1027209", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Zhang, Ming-Rong", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1027210", "nameIdentifierScheme": "WEKO"}]}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Identification and Development of a New Positron Emission Tomography Ligand 4-(2-Fluoro-4-[11C]methoxyphenyl)-5-((1-methyl-1H-pyrazol-3-yl)methoxy)picolinamide for Imaging Metabotropic Glutamate Receptor Subtype 2 (mGlu2)", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Identification and Development of a New Positron Emission Tomography Ligand 4-(2-Fluoro-4-[11C]methoxyphenyl)-5-((1-methyl-1H-pyrazol-3-yl)methoxy)picolinamide for Imaging Metabotropic Glutamate Receptor Subtype 2 (mGlu2)"}]}, "item_type_id": "8", "owner": "1", "path": ["1"], "permalink_uri": "https://repo.qst.go.jp/records/80793", "pubdate": {"attribute_name": "公開日", "attribute_value": "2020-10-09"}, "publish_date": "2020-10-09", "publish_status": "0", "recid": "80793", "relation": {}, "relation_version_is_last": true, "title": ["Identification and Development of a New Positron Emission Tomography Ligand 4-(2-Fluoro-4-[11C]methoxyphenyl)-5-((1-methyl-1H-pyrazol-3-yl)methoxy)picolinamide for Imaging Metabotropic Glutamate Receptor Subtype 2 (mGlu2)"], "weko_shared_id": -1}