WEKO3
アイテム
Enhanced Cell Inactivation and Double-strand Break Induction in V79 Chinese Hamster Cells by Monochromatic X-rays at Phosphorus K-shell Absorption Peak
https://repo.qst.go.jp/records/80725
https://repo.qst.go.jp/records/8072580b337b4-d140-43a0-bae7-338890d2fb46
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-09-19 | |||||
| タイトル | ||||||
| タイトル | Enhanced Cell Inactivation and Double-strand Break Induction in V79 Chinese Hamster Cells by Monochromatic X-rays at Phosphorus K-shell Absorption Peak | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Konishi, Teruaki
× Konishi, Teruaki× Yoshihara, Daichi× Maeda, Munetoshi× Ohsawa, Daisuke× Usami, Noriko× Hieda, Kotaro× Teruaki, Konishi× Daisuke, Ohsawa |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | To investigate an enhancement of cell inactivation and DNA double-strand break (DSB) induction by the K-shell ionization of phosphorus atoms and Auger electrons, monochromatic X-rays on and below the phosphorus K-shell absorption peak, 2.153 keV and 2.147 keV were exposed to Chinese hamster lung fibroblast V79 cells. Survival fractions were plotted against exposure, Ψ [nC/kg] and the linear-quadratic (LQ) model was adapted to estimate the parameters, α and β, of the survival curves. DSB induction rate [DSB/cell/Ψ] was estimated from the measured fractions of induced DNA fragments below 4.6 Mbp (Fk<4.6Mbp), which were determined using pulse field gel electrophoresis. As results, both cell inactivation and DSB induction rate of on the peak were significantly higher compared to that of the below. However, when converting Ψ to absorbed dose (Gy) of cell nucleus, the enhanced effect was only observed for parameter α, and not for a survival dose (Gy) of 37%, 10%, and 1% nor for a DSB induction rate. Our findings indicate that enhancement of cell inactivation and DSB induction were due to the additional dose delivered to the DNA and more complex DSB lesions were induced due to the release of phosphorus K-shell photoelectrons and Auger electrons. | |||||
| 書誌情報 |
Quantum beam science 巻 4, 号 4, p. 38, 発行日 2020-10 |
|||||
| 出版者 | ||||||
| 出版者 | MDPI | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2412-382X | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.3390/qubs4040038 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.mdpi.com/2412-382X/4/4/38 | |||||
