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Neurometabolic underpinning of the intergenerational transmission of prosociality
https://repo.qst.go.jp/records/80594
https://repo.qst.go.jp/records/805947701030b-db1d-42ac-92ea-0dc8d44bf628
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-09-30 | |||||
| タイトル | ||||||
| タイトル | Neurometabolic underpinning of the intergenerational transmission of prosociality | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Okada, Naohiro
× Okada, Naohiro× Yahata, Noriaki× Koshiyama, Daisuke× Morita, Kentaro× Sawada, Kingo× Kanata, Sho× Fujikawa, Shinya× Sugimoto, Noriko× Toriyama, Rie× Masaoka, Mio× Koike, Shinsuke× Araki, Tsuyoshi× others, Many× Noriaki, Yahata |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Parent-child personality transmission can occur via biological gene-driven processes as well as through environmental factors such as shared environment and parenting style. We recently revealed a negative association between prosociality, a highly valued personality attribute in human society, and anterior cingulate cortex (ACC) γ-aminobutyric acid (GABA) levels in children at the age of 10 years. We thus hypothesized that prosociality would be intergenerationally transmitted, and that transmission would be underwritten by neurometabolic heritability. Here, we collected prosociality data from children aged 10 years and their parents in a large-scale population-based birth cohort study. We also measured ACC GABA+ and glutamate plus glutamine (Glx) levels in a follow-up assessment with a subsample of the participants (aged 11 years) using magnetic resonance spectroscopy. We analyzed the associations among children’s and parents’ prosociality and GABA+/Glx ratios. We also examined the effect of socioeconomic status (SES) and verbalized parental affection (VPA) on these associations. We found a significant positive parent-child association for prosociality (N = 3026; children’s mean age 10.2 years) and GABA+/Glx ratio (N = 99; children’s mean age 11.4 years). There was a significant negative association between GABA+/Glx ratio and prosociality in both children (N = 208) and parents (N = 128). Our model accounting for the effects of neurometabolic heritability on prosociality transmission fitted well. Moreover, in this model, a significant positive effect of VPA but not SES on children’s prosociality was observed independently of the effect of neurometabolic transmission, while SES but not VPA was significantly associated with parental prosociality. Our results provide novel insights into the neurometabolic substrates of parent-child transmission of social behavior. | |||||
| 書誌情報 |
NeuroImage 巻 218, p. 116965, 発行日 2020-09 |
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| 出版者 | ||||||
| 出版者 | Elsevier | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1053-8119 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.neuroimage.2020.116965 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.sciencedirect.com/science/article/pii/S1053811920304511 | |||||
