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Targeted Central Nervous System Irradiation of Caenorhabditis elegans Induces a Limited Effect on Motility
https://repo.qst.go.jp/records/80505
https://repo.qst.go.jp/records/80505aafd4180-acce-4b7a-890f-e553fbad62ed
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-09-08 | |||||
| タイトル | ||||||
| タイトル | Targeted Central Nervous System Irradiation of Caenorhabditis elegans Induces a Limited Effect on Motility | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Suzuki, Michiyo
× Suzuki, Michiyo× Zu, Soh (Hiroshima Univ.)× Hiroki, Yamashita (Hiroshima Univ.)× Toshio, Tsuji (Hiroshima Univ.)× Funayama, Tomoo× Suzuki, Michiyo× Funayama, Tomo |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | To clarify the tissue responsible for a biological function, that function can be experimentally perturbed by an external stimulus, such as radiation. Radiation can be precisely and finely administered and any subsequent change in function examined. To investigate the involvement of the central nervous system (CNS) in Caenorhabditis elegans’ locomotion, we irradiated a limited 20-µm-diameter area of the CNS with a single dose and evaluated the resulting effects on motility. However, whether irradiated area (beam size)-dependent or dose-dependent effects on motility occur via targeted irradiation remain unknown. In the present study, we examined the irradiated area- and dose-dependent effects of CNS-targeted irradiation on the motility of C. elegans using a collimating microbeam system and confirmed the involvement of the CNS and body-wall muscle cells around the CNS in motility. After CNS-targeted microbeam irradiation, C. elegans’ motility was assayed. The results demonstrated a dose-dependent effect of CNS-targeted irradiation on motility reflecting direct effects on the irradiated CNS. In addition, when irradiated with 1000-Gy irradiation, irradiated area (beam size)-dependent effects were observed. This method has two technical advantages: Performing a series of on-chip imaging analyses before and after irradiation and targeted irradiation using a distinct ion-beam size. | |||||
| 書誌情報 |
Biology 巻 9, 号 9, p. 289-1, 発行日 2020-09 |
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| 出版者 | ||||||
| 出版者 | MDPI | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2079-7737 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.3390/biology9090289 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.mdpi.com/2079-7737/9/9/289/htm | |||||
