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Structural polymorphism of single pDNA condensates elicited by cationic block polyelectrolytes
https://repo.qst.go.jp/records/80397
https://repo.qst.go.jp/records/80397482c0fff-b8d1-4a9e-a0ee-dc2eafab6b64
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
2020Polymers_Structural Polymorphism of Single pDNA Condensates Elicited by Cationic Block Polyelectrolytes.pdf (6.5 MB)
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| Item type | 一般雑誌記事 / Article(1) | |||||
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| 公開日 | 2020-09-01 | |||||
| タイトル | ||||||
| タイトル | Structural polymorphism of single pDNA condensates elicited by cationic block polyelectrolytes | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | article | |||||
| 著者 |
Osada, Kensuke
× Osada, Kensuke× Osada, Kensuke |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | DNA folding is a core phenomenon in genome packaging within a nucleus. Such a phenomenon is induced by polyelectrolyte complexation between anionic DNA and cationic proteins of histones. In this regard, complexes formed between DNA and cationic polyelectrolytes have been investigated as models to gain insight into genome packaging. Upon complexation, DNA undergoes folding to reduce its occupied volume, which often results in multi-complex associated aggregates. However, when cationic copolymers comprising a polycation block and a neutral hydrophilic polymer block are used instead, DNA undergoes folding as a single molecule within a spontaneously formed polyplex micelle (PM), thereby allowing the observation of the higher-order structures that DNA forms. The DNA complex forms polymorphic structures, including globular, rod-shaped, and ring-shaped (toroidal) structures. This review focuses on the polymorphism of DNA, particularly, to elucidate when, how, and why DNA organizes into these structures with cationic copolymers. The interactions between DNA and the copolymers, and the specific nature of DNA in rigidity; i.e., rigid but foldable, play significant roles in the observed polymorphism. Moreover, PMs serve as potential gene vectors for systemic application. The significance of the controlled DNA folding for such an application is addressed briefly in the last part. | |||||
| 書誌情報 |
Polymers 巻 12, 号 7, p. 1603, 発行日 2020-07 |
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| 出版者 | ||||||
| 出版者 | MDPI | |||||
