WEKO3
アイテム
Transient stealth coating of liver sinusoidal wall by anchoring two-armed PEG for retargeting nanomedicines.
https://repo.qst.go.jp/records/80394
https://repo.qst.go.jp/records/80394a948a131-141f-4db0-a328-7016f16b42b7
| アイテムタイプ | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-09-01 | |||||
| タイトル | ||||||
| タイトル | Transient stealth coating of liver sinusoidal wall by anchoring two-armed PEG for retargeting nanomedicines. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Dirisala, Anjaneyulu
× Dirisala, Anjaneyulu× Uchida, Satoshi× Toh, Kazuko× Li, Junjie× Osawa, Shigehito× A Tockary, Theofilus× Liu, Xueying× Abbasi, Saed× Hayashi, Kotaro× Mochida, Yuki× Fukushima, Shigeto× Kinoh, Hiroaki× Osada, Kensuke× Kataoka, Kazunori× Osada, Kensuke |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | A major critical issue in systemically administered nanomedicines is nonspecific clearance by the liver sinusoidal endothelium, causing a substantial decrease in the delivery efficiency of nanomedicines into the target tissues. Here, we addressed this issue by in situ stealth coating of liver sinusoids using linear or two-armed poly(ethylene glycol) (PEG)-conjugated oligo(l-lysine) (OligoLys). PEG-OligoLys selectively attached to liver sinusoids for PEG coating, leaving the endothelium of other tissues uncoated and, thus, accessible to the nanomedicines. Furthermore, OligoLys having a two-armed PEG configuration was ultimately cleared from sinusoidal walls to the bile, while OligoLys with linear PEG persisted in the sinusoidal walls, possibly causing prolonged disturbance of liver physiological functions. Such transient and selective stealth coating of liver sinusoids by two-arm-PEG-OligoLys was effective in preventing the sinusoidal clearance of nonviral and viral gene vectors, representatives of synthetic and nature-derived nanomedicines, respectively, thereby boosting their gene transfection efficiency in the target tissues. | |||||
| 書誌情報 |
Science advances 巻 6, 号 26, 発行日 2020-09 |
|||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2375-2548 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 32637625 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1126/sciadv.abb8133 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://advances.sciencemag.org/content/6/26/eabb8133/tab-pdf | |||||
